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- E-ISSN 2288-8985
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Rapid and simultaneous ddetermination of metabolites of organic solvents in human urine by high-performance liquid chromatography using a monolithic column
Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
2006, v.19 no.5, pp.433-440
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(2006). Rapid and simultaneous ddetermination of metabolites of organic solvents in human urine by high-performance liquid chromatography using a monolithic column. Analytical Science and Technology, 19(5), 433-440.
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Abstract
A HPLC/UV method was developed and validated for the rapid and simultaneous determination of urinary metabolites of organic solvents, mandelic acid, hippuric acid, phenylglyoxylic acid, ortho-, meta- and para-methylhippuric acid, using a monolithic column. The mobile phase was composed of tetrabutylammonium bromide as ion-pairing reagent with a flow rate of 2.4 mL/min. The total run time was less than 2.5 min for all six analytes. Good linearities were obtained for all the metabolites with correlation coefficients above 0.9993. Intra-day precision, accuracy and inter-day precision was 0.01~7.32%, 83.9~116.3% and 0.01~7.16%, respectively. The method was validated and confirmed by quantification of the quality assurance samples of Industrial Safety and Health Research Institute, Korea Occupational Safety and Health Agency.
- keywords
- monolithic column, urinary metabolites, organic solvents, HPLC
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