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- E-ISSN 2288-8985
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1Determination of potical purity of N-acetyl-1 -naphthylethylamine by chiral chromatography and NMR spectroscopy
Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
2010, v.23 no.1, pp.97-101
https://doi.org/10.5806/AST.2010.23.1.097
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(2010). 1Determination of potical purity of N-acetyl-1 -naphthylethylamine by chiral chromatography and NMR spectroscopy. Analytical Science and Technology, 23(1), 97-101, https://doi.org/10.5806/AST.2010.23.1.097
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Abstract
(R)-N-3,5-dinitrobenzoyl (DNB) phenylglycinol derived chiral selector was used as a HPLC chiral stationary phase (CSP) for the resolution of racemic N-acylnaphthylalkylamines. In this study, determination of optical purity was performed by both chiral chromatography and NMR spectroscopy by using the (R)-phenylglycinol derived chiral selector. The data of accuracy and precision of each optical purity value are calculated from the results of NMR and HPLC experiments by comparing with true value. Average error of the NMR method was +2.2% with average RSD of 4.54%, while that of HPLC method was -3.5% with average RSD of 3.23%.
- keywords
- chiral selector, HPLC, N-acylnaphthylalkylamines, optical purity, NMR
Reference
1
1. Knowles, Angew. Chem. Int. Ed. 41, 1998-2007(2002).
2
2. Noyori, Angew. Chem. Int. Ed. 41, 2008-2023(2002).
3
3. Sharpless, Angew. Chem. Int. Ed. 41, 2024-2032(2002).
4
4. M. L. Lorin, R. Delpe, M. Adamczyk and P. Morin, J. Chromatogr. A 1206, 123-130(2008).
5
5. W. Dougherty, F. Liotta, D. Mondimore and W. Shum, Tetrahedron Letters 31, 4389-4390(1990).
6
6. J. Shen, S. Zhao, J. Chromatogr. A 1059, 209-214(2004) .
7
7. O. M. Demchuk, W. wierczynska, K. M. Pietrusiewicz, M. Wonica, D. Wjcik and J. Frelek, Tetrahedron: Asymmetry 19, 2339-2345(2008).
8
8. M. Sawada, H. Yamaoka, Y. Takai, Y. Kawai, H. Yamada, T. Azuma, T. Fujioka and T. Tanaka, Inter. J. Mass Spectrometry 193, 123-130(1999).
9
9. J. J. Ryoo, S. H. Im, K-. P. Lee, J. H. Park and M. H. Hyun, Microchemical J. 63, 128-133(1999).
10
10. K. H. Kim, H. J. Kim, J.-H. Kim, J. H. Lee and S. C. Lee, J. Pharm. & Biomed. Anal. 25, 947-956(2001).
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