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- E-ISSN 2288-8985
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Optimization of analytical conditions for the determination of nitrosamines in chlorinated tap water by high performance liquid chromatography
Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
2010, v.23 no.6, pp.551-559
https://doi.org/10.5806/AST.2010.23.6.551
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(2010). Optimization of analytical conditions for the determination of nitrosamines in chlorinated tap water by high performance liquid chromatography. Analytical Science and Technology, 23(6), 551-559, https://doi.org/10.5806/AST.2010.23.6.551
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Abstract
This study was conducted to establish an analytical method for the determination of seven nitrosamines in chlorinated tap water by precolumn derivatization followed by high performance liquid chromatography coupled with fluorescence detection. The derivatization procedure was optimized for denitrosation and dansylation, and then two extraction methods, liquid-liquid extraction (LLE) with dichloromethane and solid phase extraction (SPE), were compared. The SPE method employing the optimized derivation procedure showed higher extraction recovery (54.4-88.7%) and reproducibility (1.9-19.4%) than the LLE method (51.4-87.7% and 4.2-33.3%, respectively). The method detection limits were between 0.5 and 4.4 ng/L. When chlorinated water samples were collected from two treatment plants and ten household taps, and analyzed for nitrosamines, Nnitrosodimethylamine (NDMA) was the major compound found between 26.1 and 112 ng/L.
- keywords
- chlorinated tap water, dansylation, HPLC, nitrosamines, solid-phase extraction
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