- P-ISSN 1225-0163
- E-ISSN 2288-8985
- 권한신청
- P-ISSN1225-0163
- E-ISSN2288-8985
- SCOPUS, ESCI, KCI
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Analysis of erectile dysfunction drugs and their analogues in counterfeit drugs and herbal medicines by LC-ESI-MS/MS
분석과학 / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
2016, v.29 no.4, pp.155-161
https://doi.org/10.5806/AST.2016.29.4.155
(식품의약품안전처, 식품의약품안전평가원)
(식품의약품안전처)
(식품의약품안전처 식품의약품안전평가원 첨단분석팀)
(식품의약품안전처 식품의약품안전평가원 첨단분석팀)
(식품의약품안전청)
(식품의약품안전처)
(식품의약품안전처 식품의약품안전평가원 첨단분석팀)
(식품의약품안전처)
(식품의약품안전처 식품의약품안전평가원 첨단분석팀)
(식품의약품안전처 식품의약품안전평가원 첨단분석팀)
(식품의약품안전청)
(식품의약품안전처)
(식품의약품안전처 식품의약품안전평가원 첨단분석팀)
이지현,
정지혜,
박형준,
도정아,
허석,
조수열,
&
윤창용.
(2016). . 분석과학, 29(4), 155-161, https://doi.org/10.5806/AST.2016.29.4.155
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Abstract
Distribution of various illegal or counterfeit drugs of seven approved erectile dysfunction drugs and their analogues has been increased, causing health problems such as cardiovascular disorder, tachycardia, headache, or vision disturbance. We used liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS) to determine the erectile dysfunction drugs and their analogues in various counterfeit drugs. Eleven erectile dysfunction drugs and their analogues were detected, with sildenafil and its analogues being the most counterfeited compounds (73.8 %), followed by tadalafil and its analogues (25.4 %). The limits of detection (LOD) and the limits of quantitation (LOQ) of liquid-type and solid-type negative samples ranged from 0.1 to 3.3 ng/mL or ng/g and from 0.3 to 10.0 ng/mL or ng/g, respectively. The recoveries ranged from 84.3 to 112.3 % and 83.2 to 110.2 %, respectively. The contents of sildenafil and tadalafil in the various counterfeit drugs ranged from 21.0 to 947.5 mg/g and from 0.2 to 170.2 mg/g, respectively.
- keywords
- erectile dysfunction drugs and their analogues, illegal or counterfeit drugs, LC-ESI-MS/MS
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