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- E-ISSN 2288-8985
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Simultaneous analysis of β-lactam antibiotics and β-blockers by LC-MS/MS
Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
2016, v.29 no.4, pp.179-185
https://doi.org/10.5806/AST.2016.29.4.179
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(2016). Simultaneous analysis of β-lactam antibiotics and β-blockers by LC-MS/MS. Analytical Science and Technology, 29(4), 179-185, https://doi.org/10.5806/AST.2016.29.4.179
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Abstract
An effective analytical method has been developed for the determination of β-blockers(atenolol, metoprolol and propranolol) and 6 β-lactams(amoxicillin, penicillin G, cefaclor, cefadroxil, cephalexin and cephradine) in water samples using two different cartridges. The samples were extracted by solid-phase extraction (SPE) with the usage of polymeric hydrophile-lipophile balance(HLB cartridges) and strong cation-exchange mixed-mode polymeric sorbent (MCX cartridges). A XDB-C18 column(1.8 μm; 3.0 mm × 100 mm) was used for the sufficient chromatographic resolution. The calibration curves showed good linearity with high correlation coefficients (>0.995). The method detection limits (MDL) and the limits of quantification(LOQ) were from 1.1 to 3.9 ng/L and from 5 to 13 ng/L, respectively. The method was applied for the determination of the target compounds in tributaries and raw water of the Han River and these were found at N.D. to 0.209 μg/L.
- keywords
- β, -blockers, β, -lactams antibiotics, SPE, LC-MS/MS
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