- P-ISSN 1225-0163
- E-ISSN 2288-8985
- P-ISSN1225-0163
- E-ISSN2288-8985
- SCOPUS, ESCI, KCI
Article Detail
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Simultaneous analysis of β-lactam antibiotics and β-blockers by LC-MS/MS
Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
2016, v.29 no.4, pp.179-185
https://doi.org/10.5806/AST.2016.29.4.179
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(2016). Simultaneous analysis of β-lactam antibiotics and β-blockers by LC-MS/MS. Analytical Science and Technology, 29(4), 179-185, https://doi.org/10.5806/AST.2016.29.4.179
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Abstract
An effective analytical method has been developed for the determination of β-blockers(atenolol, metoprolol and propranolol) and 6 β-lactams(amoxicillin, penicillin G, cefaclor, cefadroxil, cephalexin and cephradine) in water samples using two different cartridges. The samples were extracted by solid-phase extraction (SPE) with the usage of polymeric hydrophile-lipophile balance(HLB cartridges) and strong cation-exchange mixed-mode polymeric sorbent (MCX cartridges). A XDB-C18 column(1.8 μm; 3.0 mm × 100 mm) was used for the sufficient chromatographic resolution. The calibration curves showed good linearity with high correlation coefficients (>0.995). The method detection limits (MDL) and the limits of quantification(LOQ) were from 1.1 to 3.9 ng/L and from 5 to 13 ng/L, respectively. The method was applied for the determination of the target compounds in tributaries and raw water of the Han River and these were found at N.D. to 0.209 μg/L.
- keywords
- β, -blockers, β, -lactams antibiotics, SPE, LC-MS/MS
Reference
1
1. S. A. Snyder, P. Westerhoff, Y. Yoon and D. L. Sedlak, Environ. Eng. Sci., 20(5), 449-469 (2003).
2
2. J. L. C. Dorne, A. M. Ragas, G. K. Frampton, D. S. Spurgeon and D. F. Lewis, Anal. Bioanal. Chem., 387, 1167-1172 (2007).
3
3. C. Hao, R. Clement and P. Yang, Anal. Bioanal. Chem., 387, 1247-1257 (2007).
4
4. H. Yamamoto, Y. Nakamura, Y. Nakamura, C. Kitani, T. Imari and J. Sekizawa, Environ. Sci., 14, 177-193(2007).
5
5. Kimberly Mitchell, “The physiological and behavioural adjustments of the zebrafish Danio rerio exposed to the β-blocker propranolol”, Ph. D. Dissertation, University of ottawa, Ottawa, Canada, 2013.
6
6. H. B. Lee, K. Sarafin and T. E. Peart, J. Chromatogr. A, 1148, 158-167 (2007).
7
7. M. Petrovic, M. D. Hernnando, M. S. D. Cruz and D. Barcelo, J. Chromatogr. A, 1067, 1-14 (2005).
8
8. S. Castiglioni, R. Bagnati, D. Calamari, R. Fanelli and E. Zuccato, J. Chromatogr. A, 1092, 206-215 (2005).
9
9. V. F. Samanidou, E. A. Hapeshi and I. N. Papadoyannis, J. Chromatogr. B, 788, 147-158 (2003).
10
10. J. M. Cha, S. Yang and K. H. Carlson, J. Chromatogr. A, 1115, 46-57 (2006).
11
11. EPA Method 1694: Pharmaceuticals and personal care products in water.
12
12. L. Peng and T. Farkas, J. Chromatogr. A, 1179, 131-144 (2008).
13
13. H. C. Zhang, X. J. Yu, W. C. Yang, J. F. Peng, T. Xu, D. Q. Yin and X. L. Hu, J. Chromatogr. B, 879, 2998-3004 (2011).
14
14. D. Bendz, N. A. Paxeus, T. R. Ginn and F. J. Loge, J. Hazard. Mater., 122(3), 195-204 (2005).
15
15. F. Sacher, F. T. Langen, H. J. Brauch and I. Blankenhorn, J. Chromatogr. A, 938, 199-210 (2001).
16
16. M. Dolores Hernando, M. JoséGómez, Ana Agüera and Amadeo R. Fernández-Alba, Trends Analyt. Chem., 26(6), 581-594 (2007).
17
17. S.-H. Lee, H.-W. Jung, J.-Y. Jung, H.-J. Min, B.-R. Kim, C.-G. Park, J.-E. Oh, Yuu Onoda and Nobuyuki Satou, J. Kor. Soc. Environ. Eng., 35(1), 45-56 (2013).
18
18. T. P. Boeckel, S. Gandra, A. Ashok, Q. Caudron, B. T. Grenfell, S. Levin and R. Laxminarayan, Lancet Infect. Dis., 14(8), 742-750 (2014).
19
19. K. Hirte, B. Seiwert, G. Schüürmann and T. Reemtsma, Water Res., 88, 880-888 (2016).
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