- P-ISSN 1225-0163
- E-ISSN 2288-8985
- P-ISSN1225-0163
- E-ISSN2288-8985
- SCOPUS, ESCI, KCI
Article Detail
Home > Article Detail
Comparative bioavailability of synthetic vitamin C and Nutra-C (calcium ascorbate) in Korean healthy volunteers
Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
2016, v.29 no.4, pp.162-169
https://doi.org/10.5806/AST.2016.29.4.162
(CHEIL Co., LTD.)
(Seoul Pharma Laboratories, CrystalGenomics Inc.)
(Seoul Pharma Laboratories, CrystalGenomics Inc.)
(Seoul Pharma Laboratories, CrystalGenomics Inc.)
&
(2016). Comparative bioavailability of synthetic vitamin C and Nutra-C (calcium ascorbate) in Korean healthy volunteers. Analytical Science and Technology, 29(4), 162-169, https://doi.org/10.5806/AST.2016.29.4.162
- Downloaded
- Viewed
Abstract
The purpose of this study was to compare the relative bioavailability of synthetic Vitamin C and Nutra-C® (calcium ascorbate) using a randomized parallel pharmacokinetics study design. Under fasting conditions, 20 healthy volunteers were randomly allocated to receive a single oral dose (500 mg of ascorbic acid) of either synthetic Vitamin C or Nutra-C®. Fasting blood was collected pre-dose and 1, 2, 3, 4, 7 and 10 hr post-dose. The ascorbic acid content of human serum was determined using HPLC with ultraviolet detection. The fasting serum ascorbic acid concentrations of synthetic Vitamin C and Nutra-C® were 6.734 ± 2.09 ng/mL (n = 10) and 7.542 ± 2.96 ng/mL (n = 10), respectively. The bioavailability of Nutra-C® was significantly greater (128 %, p < 0.05) than that of the synthetic Vitamin C.
- keywords
- Vitamin C, Nutra-C, Bioavailability, Human serum
Reference
1
1. Y. Li and H. E. Schellhorn, Br. J. Nutr., 137, 2171-2184(2007).
2
2. A. C. Carr and B. Frei, Am. J. Clin. Nutr., 69, 1086-1107(1999).
3
3. A. R. Tricker and R. Preussmann, Mutat. Res., 259, 277-289 (1991).
4
4. R. A. Scanlan, Nitrosamines and cancer. Linus Pauling Institute website. http://lpi.oregonstate.edu/f-w00/nitrosamine. html (2000).
5
5. National Institutes of Health (NIH), Office of Dietary Supplements. Vitamin C. Dietary Supplement Fact Sheet. http://ods.od.nih.gov/factsheets/VitaminC-HealthProfessional/(2013).
6
6. K. Beck, C. A. Conlon, R. Kruger and J. Coad and W. Stonehouse, Br. J. Nutr., 105, 101-109 (2011).
7
7. L. Hallberg, M. Brune and L. Rossander, Hum. Nutr. Appl. Nutr., 40, 97-113 (1986).
8
8. N. M. Scheers and A. S. Sandberg, Br. J. Nutr., 105, 1734-1740 (2011).
9
9. C. J. Bates, K. S. Jones and L. J. Bluck, Br. J. Nutr., 91, 699-705 (2004).
10
10. A. R. Mangels, G. Block, C. M. Frey, B. H. Patterson, P. R. Taylor, E. P. Norkus and O. A. Levander, J. Nutr., 123, 1054-1061 (1993).
11
11. F. R. Keltz, C. Kies and H. M. Fox, Am. J. Clin. Nutr., 31, 1167-1171 (1978).
12
12. J. N. Hathcock, A. Azzi, J. Blumberg, T. Bray, A. Dickinson, B. Frei, I. Jialal, C. S. Johnston, F. J. Kelly and K. Kraemer, Am. J. Clin. Nutr., 81, 736-745 (2005).
13
13. M. Levine, C. Conry-Cantilena, Y. Wang, R. W. Welch, P. W. Washko, K. R. Dhariwal, J. B. Park, A. Lazarev, J. F. Graumlich and J. King, Proc. Natl. Acad. Sci., 93, 3704-3709 (1996).
14
14. S. Yung, M. Mayersohn and J. B. Robinson, J. Pharm. Sci., 71, 282-285 (1982).
15
15. H. N. Bhagavan and B. I. Wolkoff, Pharm. Res., 10, 239-242 (1993).
16
16. R. Sacharin, T. Taylor and L. F. Chasseaud, Int. J. Vitam. Nutr. Res., 47, 68-74 (1977).
17
17. K. Nyyssonen, H. E. Poulsen, M. Hayn, P. Agerbo, E. Porkkala-Sarataho, J. Kaikkonen, R. Salonen and J. T. Salonen, Eur. J. Clin. Nutr., 51, 154-163 (1997).
18
18. M. J. Bush and A. J. Verlangieri, Res. Commun. Chem. Pathol. Pharmacol., 57, 137-140 (1987).
19
19. A. J. Verlangieri, M. J. Fay and A. W. Bannon, Life Sci., 48, 2275-2281 (1991).
20
20. C. S. Johnston and B. Luo, J. Am. Diet. Assoc., 94, 779-781 (1994).
21
21. J. Gruenwald, H. J. Graubaum, R. Busch and C. Bentley, Adv. Ther., 23, 171-178 (2006).
22
22. M. S. erban, Gh. C mpeanu and E. Ionescu, Metode de Laborator n Biochimia Animal , Editura Didactica si Pedagogica, Bucuresti, Romania, 1993.
23
23. C. Papuc, A. Pop and M. erban, Metode Analitice in Biochimia Veterinara, Editura Printech, Bucuresti, Romania, 2001.
24
24. D. Balan, M. Pele, M. Artimon and G. Luta, “Bioactive compounds in sea buckthorn fruits and in some products obtained by their processing”, Revue de Cytologie et de Biologie Végétales-Le Botaniste, 28, 364-368 (2005).
25
25. N. Matei, V. Magearu, S. Birghil , and S. Dobrina , Revista de Chimie, 55(5), 294-296 (2004).
26
26. C. Cofan and C. Radovan, Sensors, 8, 3952-3969 (2008).
27
27. Y. Wang, H. Xu, J. M. Zhang and G. Li, Sensors, 8, 2043-2081 (2008).
28
28. U. Yogeswaran and S. M. Chen, Sensors, 8, 290-313(2008).
29
29. J. Chen and Y. J. Fang, Sensors, 7, 448-458 (2007).
30
30. L. G. Shaidarova, A. V. Gedmina, I. A. Chelnokova and G. K. Budnikov, J. Anal. Chem., 61, 601-608 (2006).
31
31. R. C. Matos, M. A. Augelli, C. L. Lago and L. Angnes, Anal. Chim. Acta, 404, 151-157 (2000).
32
32. P. Janda, J. Weber, L. Dunsch and A. B. P. Lever, Anal. Chem., 68, 960-965 (1996).
33
33. W. A. Behrens and R. Madere, Anal. Biochem., 165, 102-107 (1987).
34
34. R. Shakya and D. A. Navarre, J. Agric. Food Chem., 54, 5253-5260 (2006).
35
35. A. J. Melendez-Martinez, I. M. Vicario and F. J. Heredia, Food Chem., 101, 177-184 (2007).
36
36. J. Wang, M. P. Chatrathi, B. M. Tian and R. Polsky, Anal. Chem., 72, 2514-2518 (2000).
37
37. M. W. Davey, G. Bauw and M. VanMontagu, J. Chromatogr. B, 697, 269-276 (1997).
38
38. B. Klejdus, J. Petrlova, D. Potesil, V. Adam, R. Mikelova, J. Vacek, R. Kizek and V. Kuban, Anal. Chim. Acta, 520, 57-67 (2004).
39
39. T. Wu, Y. Q. Guan and J. N. Ye, Food Chem., 100, 1573-1579 (2007).
40
40. E. J. Oliveira and D. G. Watson, J. Chromatogr. B, 764, 3-25 (2001).
41
41. M. A. Kall and C. Andersen, J. Chromatogr. B, 730, 101-111 (1999).
42
42. H. Iwase and I. Ono, J. Chromatogr A, 806(2), 361-364(1998).
Other articles from this issue
- Analysis of erectile dysfunction drugs and their analogues in counterfeit drugs and herbal medicines by LC-ESI-MS/MS
- Comparative bioavailability of synthetic vitamin C and Nutra-C (calcium ascorbate) in Korean healthy volunteers
- A comparison study of 76Se, 77Se and 78Se isotope spikes in isotope dilution method for Se
- Simultaneous analysis of β-lactam antibiotics and β-blockers by LC-MS/MS
- The anti-histamine effect of water soluble alkaloids extracted from solanum nigrum L.
- The stability comparison of purified bee venom and bee venom melittin in aqueous solution
- Development of HPLC-UV method for detection and quantification of seven organic acids in animal feed
- more
Recommanded Articles
This website recommended the use the Chrome browser for journal website.