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Comparative bioavailability of synthetic vitamin C and Nutra-C (calcium ascorbate) in Korean healthy volunteers
Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
2016, v.29 no.4, pp.162-169
https://doi.org/10.5806/AST.2016.29.4.162
(CHEIL Co., LTD.)
(Seoul Pharma Laboratories, CrystalGenomics Inc.)
(Seoul Pharma Laboratories, CrystalGenomics Inc.)
(Seoul Pharma Laboratories, CrystalGenomics Inc.)
&
(2016). Comparative bioavailability of synthetic vitamin C and Nutra-C (calcium ascorbate) in Korean healthy volunteers. Analytical Science and Technology, 29(4), 162-169, https://doi.org/10.5806/AST.2016.29.4.162
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Abstract
The purpose of this study was to compare the relative bioavailability of synthetic Vitamin C and Nutra-C® (calcium ascorbate) using a randomized parallel pharmacokinetics study design. Under fasting conditions, 20 healthy volunteers were randomly allocated to receive a single oral dose (500 mg of ascorbic acid) of either synthetic Vitamin C or Nutra-C®. Fasting blood was collected pre-dose and 1, 2, 3, 4, 7 and 10 hr post-dose. The ascorbic acid content of human serum was determined using HPLC with ultraviolet detection. The fasting serum ascorbic acid concentrations of synthetic Vitamin C and Nutra-C® were 6.734 ± 2.09 ng/mL (n = 10) and 7.542 ± 2.96 ng/mL (n = 10), respectively. The bioavailability of Nutra-C® was significantly greater (128 %, p < 0.05) than that of the synthetic Vitamin C.
- keywords
- Vitamin C, Nutra-C, Bioavailability, Human serum
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