- P-ISSN 1225-0163
- E-ISSN 2288-8985
- 권한신청
- P-ISSN1225-0163
- E-ISSN2288-8985
- SCOPUS, ESCI, KCI
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Comparative bioavailability of synthetic vitamin C and Nutra-C (calcium ascorbate) in Korean healthy volunteers
분석과학 / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
2016, v.29 no.4, pp.162-169
https://doi.org/10.5806/AST.2016.29.4.162
((주)센트리온제약)
((주)센트리온제약)
(CHEIL Co., LTD.)
((주)서흥캅셀)
((주)서흥캅셀)
(Seoul Pharma Laboratories, CrystalGenomics Inc.)
(Seoul Pharma Laboratories, CrystalGenomics Inc.)
(Seoul Pharma Laboratories, CrystalGenomics Inc.)
((주)센트리온제약)
(CHEIL Co., LTD.)
((주)서흥캅셀)
((주)서흥캅셀)
(Seoul Pharma Laboratories, CrystalGenomics Inc.)
(Seoul Pharma Laboratories, CrystalGenomics Inc.)
(Seoul Pharma Laboratories, CrystalGenomics Inc.)
최경미,
김만훈,
황태원,
김종대,
박금덕,
김미영,
정영림,
&
신혜승.
(2016). . 분석과학, 29(4), 162-169, https://doi.org/10.5806/AST.2016.29.4.162
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Abstract
The purpose of this study was to compare the relative bioavailability of synthetic Vitamin C and Nutra-C® (calcium ascorbate) using a randomized parallel pharmacokinetics study design. Under fasting conditions, 20 healthy volunteers were randomly allocated to receive a single oral dose (500 mg of ascorbic acid) of either synthetic Vitamin C or Nutra-C®. Fasting blood was collected pre-dose and 1, 2, 3, 4, 7 and 10 hr post-dose. The ascorbic acid content of human serum was determined using HPLC with ultraviolet detection. The fasting serum ascorbic acid concentrations of synthetic Vitamin C and Nutra-C® were 6.734 ± 2.09 ng/mL (n = 10) and 7.542 ± 2.96 ng/mL (n = 10), respectively. The bioavailability of Nutra-C® was significantly greater (128 %, p < 0.05) than that of the synthetic Vitamin C.
- keywords
- Vitamin C, Nutra-C, Bioavailability, Human serum
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