- P-ISSN 1225-0163
- E-ISSN 2288-8985
- P-ISSN1225-0163
- E-ISSN2288-8985
- SCOPUS, ESCI, KCI
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Distributions of Pefloxacin in Flounder
Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
1999, v.12 no.1, pp.22-27
Lee,
P., &
Jang,
W.
(1999). Distributions of Pefloxacin in Flounder. Analytical Science and Technology, 12(1), 22-27.
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Abstract
This study showed the distribution of pefloxacin as a kind of quinolones after oral administrations of 100 mg/kg pefloxacin for 2 days in flounder. After administrations of pefloxacin, blood, muscle, and 8 organs including liver of flounder were analyzed by HPLC. In results, we knew that pefloxacin had absorbed from intestine and accumulated into gall bladder. In blood, maximum plasma concentration was showed <TEX>$4.70{\mu}g/ml$</TEX> at 45min, and detected <TEX>$0.31{\pm}0.01{\mu}g/ml$</TEX> at 11th day after administration. The concentration of pefloxacin was remained <TEX>$0.29{\pm}0.02{\mu}g/g$</TEX> tissue in muscle at 10th day.
- keywords
- pefloxacin, HPLC, flounder, fish
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