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Analysis of the Metabolites of 1,2,4-Trimethylbenzene by Capillary Electrophoresis
Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
1999, v.12 no.4, pp.326-331
Kang,
J., Hong,
C., Lim,
J., Lee,
Y., &
Jang,
J.
(1999). Analysis of the Metabolites of 1,2,4-Trimethylbenzene by Capillary Electrophoresis. Analytical Science and Technology, 12(4), 326-331.
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Abstract
The metabolites of 1,2,4-trimethylbenzene (TMB) were synthesized and determined by capillary electrophoresis (CE). The optimum conditions of CE for the separation and determination of 3,4-, 2,4-, 2,5-dimethylbenzoic acid and 3,4-, 2,4-, 2,5-dimethylhippuric acid from the rat urine were as following: the fused silica capillary(<TEX>$75{\mu}m$</TEX> i.d. <TEX>${\times}$</TEX> 36 cm length, 29 cm to detector) was used and kept at <TEX>$15^{\circ}C$</TEX>. The applied voltage was 10㎸ and compounds were detected at UV 210 mnm and 254 nm. The running electrolyte was 0.1 M phosphate buffer (pH 7) containing 15 mM of <TEX>${\beta}-CD$</TEX> and 3% of 2-propanol. The relative amount of the metabolite of 1,2,4-TMB in the rat urine was 56.7% of 3,4-isomer, 30.5% of 2,4-isomer and 12.8% of 2,5-isomer. This method can be applied to the analysis of TMB-metabolites in human urine.
- keywords
- capillary electrophoresis, trimethylbenzene, dimethylbenzoic acid, dimethylhippuric acid, metabolites
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