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- E-ISSN 2288-8985
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Analysis of residual neomycin in honey by LC-MS/MS
Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
2009, v.22 no.4, pp.319-325
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(2009). Analysis of residual neomycin in honey by LC-MS/MS. Analytical Science and Technology, 22(4), 319-325.
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Abstract
An effective and specific procedure for confirmation of neomycin, aminoglycoside antibiotic in honey was developed and validated. Honey was adjusted to pH 2 with 0.1M HCl and applied to weak cation-exchange SPE cartridge. Neomycin was eluted with basified methanol. Following separation by ion-pairing liquid chromatography, neomycin was analysed with positive electrospray ionization and MRM mode. Quantification was linear over the range of 5.0~250.0 ㎍/㎏ (r<SUP>2</SUP>＞0.9951). The precision (R.S.D.) and accuracy (as a bias) of quality control samples in honey ranged 11.5~18.7% and 10.9~20.9%, respectively. Established method can be applied to analysis of neomycin in honey
- keywords
- Honey, neomycin, LC-MS/MS
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