- P-ISSN 1225-0163
- E-ISSN 2288-8985
- Log In/Sign Up
- P-ISSN1225-0163
- E-ISSN2288-8985
- SCOPUS, ESCI, KCI
Article Detail
Home > Article Detail
Development and validation of a selective and sensitive LC-MS/MS method for determination of misoprostol acid in human plasma: Application to bioequivalence study
Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
2015, v.28 no.1, pp.17-25
https://doi.org/10.5806/AST.2015.28.1.17
(Bio-Medieng Co. Ltd)
(Bio-Medieng Co. Ltd)
(Bio-Medieng Co. Ltd)
(Bio-Medieng Co. Ltd)
(Bio-Medieng Co. Ltd)
(Bio-Medieng Co. Ltd)
(Bio-Medieng Co. Ltd)
(Bio-Medieng Co. Ltd)
(Bio-Medieng Co. Ltd)
(Bio-Medieng Co. Ltd)
(Bio-Medieng Co. Ltd)
(Bio-Medieng Co. Ltd)
(Bio-Medieng Co. Ltd)
Yong,
S.
P.
, Keun,
N.
K.
, Ye,
N.
K.
, Jung,
H.
K.
, Jin,
Y.
K.
, Soo,
J.
S.
, &
Heon,
S.
L.
(2015). Development and validation of a selective and sensitive LC-MS/MS method for determination of misoprostol acid in human plasma: Application to bioequivalence study. Analytical Science and Technology, 28(1), 17-25, https://doi.org/10.5806/AST.2015.28.1.17
- Downloaded
- Viewed
Abstract
A rapid, sensitive and specific method was developed and validated using electrospray ionization(ESI) tandem mass spectrometry (LC-MS/MS) for determination of misoprostol acid in human plasma. Misoprostolacid-d5 was used as in internal standard (IS). The analyte and IS were extracted by simple one step solid phaseextraction (SPE). Linearity in plasma was obtained over the concentration range 10~3000 pg/mL and lowerlimit of quantification (LLOQ) was identifiable and reproducible at 10 pg/mL. The intra- and inter-day precisionvalues were below 9% and the accuracy was ranged from 93.81% to 102.02% at all four quality control samples. The method was has been successfully applied for routine assay to support pharmacokinetic study of misoprostolacid in human plasma after an oral administration of 0.4 mg misoprostol.
- keywords
- misoprostol acid, alsoben, human plasma, LC-MS/MS, pharmacokinetics
Reference
1
1. P. W. Collins, Med. Res. Rev., 110, 149-172 (1990).
2
2. R. D. Newman, N. Citlin, E. J. Lacayo, A. V. Safdi, E. J. Ramsey, S. L. Engel, A. Rubin, C. H. Nilsen and E. A. Swabb, Am. J. Med., 83(1A), 27-31 (1987).
3
3. A. Robert, Gastroenterology, 77, 761-767 (1979).
4
4. Metin Gülmezoglu, José Villar, Nguyen Thi Nhu Ngoc, Gilda Piaggio, Guillermo Carroli and Lekan Adetoro, et al, Lancet, 358, 689-695 (2001).
5
5. G. Schoenhard, J. Oppermann and F. E. Kohn, Dig. Dis. Sci., 30(11), 126S-128S (1985).
6
6. A. Karim, L. F. Rozek, M. E. Smith and K. G. Kowalski, J. Clin. Pharmacol, 29, 439-443 (1989).
7
7. E. F. Foote, D. R. Lee, A. Karim, W. F. Keane and C. E. Halstenson, J. Clin. Pharmacol, 35(4), 384-9 (1995).
8
8. M. Zieman, S. K. Fong, N. L. Benowitz, D. Banskter, P. D. Darney, Obstet Gynecol, 90(1), 88-92 (1997).
9
9. O. S. Tang, H. Schweer, H. W. Seyberth, S. W. Lee and P. C. Ho, Hum Reprod, 17(2), 332-336 (2002).
10
10. B. Watzer, H. W. Seyberth and H. Schweer, J. Mass Spectrom, 37(9), 927-33 (2002).
11
11. H. Abdel-Aleem, J. Villar, A. M. Gülmezoglu, S. A. Mostafa, A. A. Youssef, M. Shokry and B. Watzer, Eur J. Obstet Gynecol Reprod Biol., 108, 25 (2003).
12
12. K. G. Danielsson, L. Marions, A. Rodriguez, B. W. Spur, P. Y. Wong and M. Bygdeman, Obstet Gynecol, 93(2), 275-280 (1999).
13
13. K. L. Andolina, J. E. Tolosa, J. M. Monzo, N. S. Roberts and S. Daly, J. Matern. Fetal Neonatal Med., 14(4), 229-232 (2003).
14
14. Y. Zou, X. Chen, B. Song and D. Zhong, J. Chromatography B., 852, 122-127 (2007).
15
15. C. Fiala, A. Aronsson, F. Granath, O. Stephansson, H. W. Seyberth, B. Watzer and K. Gemzell-Danielsson, Hum Reprod., 20(12), 3414-3418 (2005).
Other articles from this issue
- Development of a method for the determination of 4-(methylnitrosamino)- 1-(3-pyridyl)-1-butanone in dust using liquld chromatography tandem mass spectrometry
- Electrochemical gas sensor based on Pt-Ru-Mo/MWNT electrocatalysts and vinyl ionic liquids as electrolyte
- Development and validation of a selective and sensitive LC-MS/MS method for determination of misoprostol acid in human plasma: Application to bioequivalence study
- Evaluation of the consistency and homogeneity of artificial latent fingerprint printed with artificial sweat
- Characterization of CdS-quantum dot particles using sedimentation field-flow fractionation (SdFFF)
- Optimization of hydrochar generated from real food waste using titration methods
- Acidification and neutralization characteristics of size-fractionated atmospheric aerosols at Gosan site of Jeju Isalnd
- Concentration distributions and formation characteristics of trihalomethanes in drinking water supplies to rural communities
- Development of intracellular organelle markers using modified glycolipid-binding peptides in mammalian cells
- Effect of Angelica gigas extract powder on progress of osteoarthritis induced by monosodium iodoacetate in rats
- more
Recommanded Articles
This website recommended the use the Chrome browser for journal website.