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  • P-ISSN1225-0163
  • E-ISSN2288-8985
  • SCOPUS, ESCI, KCI

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  • P-ISSN 1225-0163
  • E-ISSN 2288-8985

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    Development and validation of a selective and sensitive LC-MS/MS method for determination of misoprostol acid in human plasma: Application to bioequivalence study

    분석과학 / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
    2015, v.28 no.1, pp.17-25
    https://doi.org/10.5806/AST.2015.28.1.17
    Yong Sun Park (Bio-Medieng Co. Ltd)
    Keun Nam Kim (Bio-Medieng Co. Ltd)
    Ye Na Kim (Bio-Medieng Co. Ltd)
    Jung Hwan Kim (Bio-Medieng Co. Ltd)
    Jin Young Kim (Bio-Medieng Co. Ltd)
    Soo Ji Sim (Bio-Medieng Co. Ltd)
    Heon Soo Lee (Bio-Medieng Co. Ltd)
    Yong, S. P. , Keun, N. K. , Ye, N. K. , Jung, H. K. , Jin, Y. K. , Soo, J. S. , & Heon, S. L. (2015). . 분석과학, 28(1), 17-25, https://doi.org/10.5806/AST.2015.28.1.17
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    Abstract

    A rapid, sensitive and specific method was developed and validated using electrospray ionization(ESI) tandem mass spectrometry (LC-MS/MS) for determination of misoprostol acid in human plasma. Misoprostolacid-d5 was used as in internal standard (IS). The analyte and IS were extracted by simple one step solid phaseextraction (SPE). Linearity in plasma was obtained over the concentration range 10~3000 pg/mL and lowerlimit of quantification (LLOQ) was identifiable and reproducible at 10 pg/mL. The intra- and inter-day precisionvalues were below 9% and the accuracy was ranged from 93.81% to 102.02% at all four quality control samples. The method was has been successfully applied for routine assay to support pharmacokinetic study of misoprostolacid in human plasma after an oral administration of 0.4 mg misoprostol.

    keywords
    misoprostol acid, alsoben, human plasma, LC-MS/MS, pharmacokinetics


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