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- E-ISSN 2288-8985
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Effect of Angelica gigas extract powder on progress of osteoarthritis induced by monosodium iodoacetate in rats
Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
2015, v.28 no.1, pp.72-77
https://doi.org/10.5806/AST.2015.28.1.72
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(2015). Effect of Angelica gigas extract powder on progress of osteoarthritis induced by monosodium iodoacetate in rats. Analytical Science and Technology, 28(1), 72-77, https://doi.org/10.5806/AST.2015.28.1.72
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Abstract
To study the efficacy of extract powder of Angelica gigas in preventing and treating degeneration of thearticular cartilage in rats with monosodium iodoacetate (MIA)-induced osteoarthritis, A total of 30 six-week-oldSprague-Dawley rats were randomly divided into normal control group, untreated group and Angelica gigas treatedgroup, with 10 rats in each group. During the treatment period, body weight were measured in each four days intervalfrom starting date. The rat were sacrificed at the end of 3rd week after daily administration of Angelica gigas andthen rat tibia articular cartilage was removed. In articular cartilages, glycosaminoglycan (GAG) amount increasedby MIA treatment were reduced while proteoglycan (PG) amount decreased by MIA treatment were fairly recoveredby Angelica gigas treatment, respectively. The content of TNF-a was also slightly reduced sections of the cartilagewere stained with safranin-0 were also partially recovered by Angelica gigas treatment. By HPLC analysis, the contentof main compounds decursin and decursinol angelate was analyzed as 10.5 ± 0.2% of total extracts.
- keywords
- Angelica gigas, monosodium iodoacetate, osteoarthritis, glycosaminoglycan, proteoglycan
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