- P-ISSN 1225-0163
- E-ISSN 2288-8985
- 권한신청
- P-ISSN1225-0163
- E-ISSN2288-8985
- SCOPUS, ESCI, KCI
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LC-MS/MS를 이용한 건강기능식품 내 항히스타민20종 동시분석법 개발
Development of a LC–MS/MS method for simultaneous analysis of 20 antihistamines in dietary supplements
분석과학 / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
2015, v.28 no.2, pp.86-97
https://doi.org/10.5806/AST.2015.28.2.86
(식품의약품안전처)
(식품의약품안전처)
(식품의약품안전처)
(식품의약품안전처)
(식품의약품안전처, 식품의약품안전평가원)
(식품의약품안전처, 식품의약품안전평가원)
(식품의약품안전처 식품의약품안전평가원 첨단분석팀)
(식품의약품안전처)
(식품의약품안전처)
(식품의약품안전처)
(식품의약품안전처)
(식품의약품안전처)
(식품의약품안전처, 식품의약품안전평가원)
(식품의약품안전처, 식품의약품안전평가원)
(식품의약품안전처 식품의약품안전평가원 첨단분석팀)
(식품의약품안전처)
(식품의약품안전처)
도정아,
김정연,
최지연,
이지현,
김형주,
노은영,
조소현,
윤창용,
&
김우성.
(2015). LC-MS/MS를 이용한 건강기능식품 내 항히스타민20종 동시분석법 개발. 분석과학, 28(2), 86-97, https://doi.org/10.5806/AST.2015.28.2.86
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- 조회수
Abstract
Recently, the consumption of dietary supplements has increased because of people’s greater interest in health. Unfortunately, the sales of dietary supplements containing unauthorized substances such as drugs have also increased. We developed a rapid, accurate method for the simultaneous determination of antihistamines using liquid chromatography tandem mass spectrometry with a multiple reaction monitoring mode. The limit of detection (LOD) and limit of quantification (LOQ) of the instrument used in this method were in the ranges 0.0003-0.3 and 0.0009-0.6 μg mL−1, respectively. The linearity of the method was > 0.99. The precision levels of the method were 0.1-9.8% (intra-day) and 0.3-9.6% (inter-day), and the levels of accuracy of the method were 82.7-115.0% (intra-day) and 84.3-113.0% (inter-day). The mean of recovery of the method was in the range of 83.9-117.9% and the RSD of the stability was less than 5.9%.
- keywords
- LC-MS/MS, antihistamines, dietary supplements, unauthorized substances, multiple reaction monitoring
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