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Validation of acid-base titration equivalence between spectroscopic titrator (SPT) and conventional titrators
Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
2021, v.34 no.6, pp.267-274
https://doi.org/10.5806/AST.2021.34.6.267
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(2021). Validation of acid-base titration equivalence between spectroscopic titrator (SPT) and conventional titrators. Analytical Science and Technology, 34(6), 267-274, https://doi.org/10.5806/AST.2021.34.6.267
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Abstract
Acid-base titration experiments were carried out using the same sample to obtain a direct comparison of analysis results between a new titrator and conventional Spectrator (SPT) titrators. This allowed the confirmation of an endpoint both by spectroscopic detection and by conventional titrators (automatic burette (ABT) and autotitrator (ATT)). Statistical analysis was performed on the measured values (endpoints) obtained using different titrators, to assess their differences by comparison of straightness, equivalence, ANOVA, F-test, and t-test results. The coefficients of determination, confirmed by straightness, were all >0.999. Thus, the null hypothesis that there was no statistical difference could not be rejected. The Bland-Altman analysis method was used to confirm agreement with the new experimental method. No discrepancy was found in the measured values obtained using different titrators used in this study.
- keywords
- automatic burette, autotitrator, spectrator, statistic analysis, bland-altman plot
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