The purpose of this study was to investigate factors affecting the adolescent's health literacy. First, we examined whether information literacy affects adolescents' understanding of health information, and then analyzed how demographic statistics and various other characteristics of adolescents affect health literacy. Data was collected through a survey of 277 middle and high school students. The results of analysis of Multi-regression showed that information literacy was found to have a positive impact on adolescent's health literacy. In addition, factors such as gender, grade level, academic performance, health concern, and frequency of use of digital devices were statistically significant in their affect on adolescent's health literacy. The results of this study can be used as basic data to improve adolescent' comprehension of health information.