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Analysis of amino acids in the liver of Hamster treated with Dimethylnitrosamine
Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
1994, v.7 no.2, pp.165-171
Kim,
S. G., Jung,
H. S., &
Park,
T.
K.
(1994). Analysis of amino acids in the liver of Hamster treated with Dimethylnitrosamine. Analytical Science and Technology, 7(2), 165-171.
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Abstract
The effect of the chemical carcinogen dimetylnitrosamine(DMN) on the composition of amino acids of the liver in hamsters orally administered with DMN was studied by using the reversed phase high performance liquid chromatography technique. In the liver, the concentration of aspartic acid, glycine, glutamine, histidine, proline, tyrosine and leucine were increased ca. 2-fold of those observed in liver of control group, valine and tryptophan were increased ca. 3-fold, phenylalanine was markedly increased ca. 10-fold, whereas the concentration of threonine was decreased, serine, alanine, arginine, methionine, isoleucine and lysine were unchanged, respectively.
- keywords
- DMN, Amino acids, reversed phase HPLC
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