Article Detail

Home > Article Detail
  • P-ISSN 1225-0163
  • E-ISSN 2288-8985

Simultaneous analysis of β-lactam antibiotics in surface water

Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
2010, v.23 no.2, pp.119-127
https://doi.org/10.5806/AST.2010.23.2.119


  • Downloaded
  • Viewed

Abstract

An effective method for the simultaneous analysis of β-lactams from surface water was established. After solid-phase extraction with HLB (Hydrophilic Lipohilic Balance) cartridge at pH 2, seven β-lactams (amoxicillin, ampicillin, penicillin G, cefaclor, cefadroxil, cefatrizine and cephradine) were determined using LC/ESI-MS/MS. In this newly established method, correlation coefficients (r2) of calibration curves for seven β-lactams in blank surface water appeared to be 0.9911~0.9995 in the concentration range of 0.01~1.0 ng/mL. The limits of detection (LODs) and the limits of quantificaiton (LOQs) in spiked surface water were shown to be 0.0003~0.0234 ng/mL and 0.0046~0.0778 ng/mL, respectively. The developed method is believed to serve as a rapid and reliable method for the qualitative and quantitative analysis of residual β-lactam antibiotics from aquatic environment.

keywords
<TEX>${\beta}$</TEX>-lactam, surface water, LC/MS/MS, residual analysis


Reference

1

1. W. M. A. Niessen, J. Chromatogr. A, 812, 53-75(1998)

2

2. W. G. Huber, Adv. Environ. Sci. Technol. 2, 289-320(1971).

3

3. J. M. Cha, S. Yang and K. H. Carlson, J. Chromatogr. A, 1115, 46-57(2006).

4

4. J. P. Hou and J. W. Poole, J. Pharm. Sci. 60, 503- 532(1971).

5

5. F. Bruno, R. Curini, A. D. Corcia, M. Nazzari and R. Samperi, Rapid Commun. Mass Spectrom. 15, 1391- 1400(2001).

6

6. K. L. Tyczkowska, R. D. Voyksner and A. L. Aronson, J. Chromatogr. A, 594, 195-201(1992).

7

7. T. Christian, R. J. Schneider, H. A. Faber, D. Skutlarek, M. T. Meyer, H. E. Goldbach, Acta Hydrochim. Hydrobiol. 31, 36-44(2003).

8

8. R. Hirsch, T. A. Ternes, K. Haberer, A. Mehlich, F. Ballwanz and K. Kratz, J. Chromatogr. A, 815, 213- 223(1998).

9

9. R. Hirsch, T. Ternes, K. Haberer, and K. L. Kratz, Sci. Total Environ. 225, 109-118(1999).

10

10. F. Sacher, F.T. Lange, H. Brauch and I. Blankenhorn, J. Chromatogr. A, 938, 199-210(2001).

상단으로 이동

Analytical Science and Technology