Purpose – Several previous studies have been completed on oriental art therapy’s impact on problem-solving and innovation in business workers. However, there is a definite research gap in how it reduces stress within the impacts oriental art therapy on business workers. Therefore, this research will be significant in finding out what oriental art therapy has reduced work-related stress and increased satisfaction among business workers. Research design, data, and methodology – For this research, the dependent variable was the significance of oriental art therapy, and the dependent variable was reducing work-related stress and increasing the satisfaction of business workers. The study's hypothesis was oriental art therapy reduces work-related stress and increases the satisfaction of business workers. A quantitative quasi-experimental pilot design was the most appropriate for this study. Result – This research figured out that the art therapy affect significantly reducing work-related stress among business workers, removing the level of anxiety, improving employee’s feeling, and so leading to improvement in communication and collaboration each other in the organization. Conclusion – The results of the investigation imply that oriental art therapy can significantly improve the workers' satisfaction in a business. The research shows how successfully some of the interventions introduced in the medical supply company fully transformed the workers' lives.