This study explored the differences of psychological distress, non-dailiness, health behavior, and the influences of non-dailiness, health behavior on negative-affect, anxiety, burnout, somatization among gender and age groups during COVID-19. Online survey was conducted among 1,434 participants between February 19, 2021 and March 3. According to multiple-regression analysis, for women in 20/30s ‘parenting-difficulties’ predicted negative-affect, burnout, ‘social media-induced sleep problems' predicted negative-affect, anxiety, somatization, ‘the need for mental health care' predicted negative-affect, burnout, somatization. For men in 20/30s, ‘reluctance to use public transportation' predicted burnout, ‘activity-constraints' predicted negative-affect, ‘alcohol-assumption' predicted burnout, somatization, ‘social media-induced sleep problems' predicted anxiety, burnout, somatization, ‘preventive behaviors' predicted negative-affect, and ‘the need for mental health care' predicted negative-affect, somatization. For women over 40s, ‘reluctance to use public transportation' predicted negative-affect, ‘activity-constraints' predicted negative-affect, anxiety, ‘income-decreasing' predicted negative-affect, burnout, somatization, ‘social media-induced sleep problems' predicted negative-affect, anxiety, burnout, somatization, and ‘the need for mental health care' predicted negative-affect, anxiety, burnout, somatization. For men over 40s. ‘reluctance to use public transportation' predicted negative-affect, burnout, ‘parenting-difficulties’ predicted burnout, ‘social media-induced sleep problems' predicted negative-affect, anxiety, burnout, somatization, 'alcohol-assumption' predicted anxiety, burnout, somatization, and ‘the need for mental health care' predicted burnout, somatization. Implications and recommendations are presented.