The aim of this study is to examine the mechanism through the gratitude disposition leads to life satisfaction. To this purpose, this study was to investigate the effect of gratitude disposition on life satisfaction. And it also was to verify whether there are the mediating effect of social support and the moderated mediating effect of self-esteem. In this regard, the theoretical background and previous studies on gratitude disposition, social support, self-esteem, and life satisfaction were reviewed, and research model and hypotheses were derived based on these reviews. In this study, hypotheses were verified using SPSS process macro with 388 sample data collected by a survey of men and women in their 20s or older working at beauty shops located in the Seoul metropolitan area. As a result of the study, first, it was found that gratitude disposition had a positive effect on life satisfaction. Second, it was found that social support mediated the positive relationship between gratitude disposition and life satisfaction. Third, it was found that self-esteem moderated the effect of social support on life satisfaction. In other words, when self-esteem was higher than when self-esteem was low, the positive relationship between social support and life satisfaction was stronger. Finally, self-esteem moderated the mediating relationship between gratitude disposition and life satisfaction via social support, and those with higher self-esteem were found to be larger than those with lower self-esteem. This study showed that gratitude disposition of beauty shop workers can have a positive effect on life satisfaction through the mediating effect of social support, and in this process, by integrating and verifying the mediating effect of social support and the moderated mediating effect of self-esteem, the comprehensive mechanism about the effect of gratitude disposition on life satisfaction can be further understood.