The purpose of this paper is to review a lot of clinical feature and risk factor of depression during the midlife. Several studies of depression had been reported that it was related to marital conflicts. Midlife women with depression are at risk for view of aging, crisis of ego-identity and marital conflicts. Now we need to pay attention to the martial therapy for depression. In this paper, four cases of women's depression including a treatment case were introduced. A integrative marital therapy might be effective the treatment of depression with chronicity and severity. Finally, the effect and limit of a integrative marital therapy for couple including a depressive wife were suggested.
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