Objective. The study was conducted to test the potential moderating effect of affective responsiveness on the relationship between Hwa-byung state, Hwa-byung trait, and life satisfaction. Methods. 67 responses were collected from family caregivers of patients diagnosed with gastric cancer at the Samsung Medical Center, South Korea. Results. The current findings explain the statistical significance of the impact of Hwa-byung state on caregivers’ life satisfaction. Moreover, affective responsiveness of family functioning showed an interaction effect on the relationship between Hwa-byung state and life satisfaction. Conclusions. The result implies that providing psychoeducation and psycho-social interventions, such as family therapy, should be taken into account to promote life satisfaction of caregivers.