The study examined the mediated moderating effect of grit through social support on the relationship between work-family conflict and life satisfaction of working mothers. Data from 288 working mothers were analyzed via SPSS 26.0 and SPSS PROCESS Macro (v.3.5). First, work-family conflict was negatively related to grit, social support and life satisfaction. Grit was positively correlated with social support and life satisfaction. and social support was positively correlated with life satisfaction. Second, the relationship between work-family conflict and life satisfaction was partially mediated by social support. Third, grit moderated the effect of work-family conflict on life satisfaction. Fourth, the mediated moderation effect of grit in the relationship between work-family conflict, social support from family, and life satisfaction was statistically significant. For social support from colleagues, the interaction effect of work-family conflict and grit was not significant This study is meaningful in that it explained the mediating effect of social support as work-family conflicts affect life satisfaction of working mothers. Specifically, the study revealed that grit, a personal psychological characteristic of working mothers, can help increase life satisfaction in the context of high work-family conflict. Interventions should seek ways to increase grit and family social support of working mothers.