The purpose of this study was to explore the role of acceptance for differences and conflict resolution strategies on the association between Big 5 personality traits and couple relationship satisfaction. The Acceptance for Differences in Couple Relationships Scale (ADCRS) and other self-reporting scales were administered to 300 adults. The ADCRS was positively correlated with openness, conscientiousness, agreeableness, and positive conflict resolution strategies, and negatively correlated with neuroticism and negative conflict resolution strategies. The ADCRS showed a stronger effect on relationship satisfaction than conflict resolution strategies. The mediation roles of acceptance for differences and conflict resolution strategy in the association between personality traits and couple relationship satisfaction were different depending on personality traits. Also, the effect of personality traits on couple satisfaction, and the mediating effect of acceptance for differences were stronger in men than in women. Finally, Implications and limitations of the study have been discussed.