The purpose of this study is to examine the mediating effects of the irrational beliefs on the relationship between college female students’ premenstrual syndrome (PMS) and menstrual Attitudes. In this study 251 female students in Daegu and Gyeongbuk have been surveyed, but out of the 251 participants, 3 were of extreme age in comparison to the other participants and two students’ answers were unreliable. After taking this into consideration the study was conducted by using a total of 246 participants. The results are as follows. First, significant positive correlation was identified between PMS experience, menstrual attitudes, and irrational beliefs. Second, PMS experience of the subjects significantly affected their menstrual attitudes. Among the subfactors of PMS experience, behavior change, concentration, autonomic nerve system response accounted for 22.4%, therefore becoming the significant predictive factor. Third, irrational beliefs turned out to have a significant mediator effect in the relationship between PMS and menstrual attitudes of the subjects. This study shows that out of all the factors, which influence the PMS experience, irrational beliefs is the most significant factor. Finally, discussion of the results’ implications and proposal of further investigations are described.