Purpose: Blockchain technology is becoming increasingly important in e-commerce trading applications thanks to the many benefits it brings. The research aims to understand the factors affecting the behavior of using blockchain-integrated supply chain management systems on e-commerce distribution channel. Research design, data and methodology: Based on the UTAUT2 model, a theoretical research model was developed. Data was collected from 348 buyers who are using a blockchain-integrated SCM system. Results: The results of testing the hypotheses showed that performance expectancy, effort expectancy, social influence, facilitating conditions, hedonic motivation, and price value had a positive impact on behavior intention. The outcomes further demonstrated that use behavior is directly impacted by behavior intention. The findings also supported the study model's behavior intention's mediating function. Conclusions: This has confirmed that the application and integration of blockchain technology into the supply chain management system is being very well received in Vietnam. Policy recommendations and suggestions for businesses are based on these results. This result contributes to the TAM and TPB theories on usage behavior through the promotion of factors influencing behavior intention. The implications drawn from the research results help businesses and managers make effective decisions in promoting the use of blockchain technology on e-commerce distribution channel.