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바이오 분야 학술 문헌에서의 분야별 관계 추출 데이터셋 반자동 구축에 관한 연구 - 알츠하이머병 유관 유전자 간 상호 작용 중심으로 -
A Study on the Semiautomatic Construction of Domain - Specific Relation Extraction Datasets from Biomedical Abstracts - Mainly Focusing on a Genic Interaction Dataset in Alzheimer’s Disease Domain -
유석종 (한국과학기술정보연구원)
조현양 (경기대학교)
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초록
본 논문에서는 생의학 분야의 특정 세부 분야에 특화된 관계 추출 학습 말뭉치를 효율적으로 구축할 수 있는 시스템을 소개한다. 이 시스템은 대상 분야에 해당하는 용어집(유전자, 단백질, 질환 명칭 등)을 입력하면, 대용량 상호 작용 데이터베이스를 통해서 이들 용어 간의 연관 관계를 1차적으로 생성하고 생성된 연관 관계 집합을 다시 학술 데이터베이스에서 검색하여 최종적으로 연관 관계 포함 문장을 추출하는 형태로 수행된다. 개발된 시스템의 유용성 검증을 위해서 알츠하이머 병 분야에서의 유전자 간 상호 작용 학습 말뭉치를 구축하는데 본 시스템을 적용하였고, 140개의 유전자 집합을 입력하여 이 분야에 특화된 학습 집합인 유전자 쌍 및 상호 작용 포함 문장 3,510 건을 추출하였다. 본 논문에서 제안한 시스템을 활용함으로써 기존에 완전 수작업으로 수행되던 연관 관계 추출용 학습 말뭉치 구축의 효율성을 높일 수 있고 다양한 세부 분야에 적합한 학습 말뭉치 구축에 도움을 줄 수 있다.
- keywords
- 관계 추출, 학습 집합 구축, 유전자 간 상호 작용, 기계 학습, 텍스트 마이닝, Relation extraction, Dataset construction, Genic interactions, Machine learning, Text mining
Abstract
This paper introduces a software system and process model for constructing domain-specific relation extraction datasets semi-automatically. The system uses a set of terms such as genes, proteins diseases and so forth as inputs and then by exploiting massive biological interaction database, generates a set of term pairs which are utilized as queries for retrieving sentences containing the pairs from scientific databases. To assess the usefulness of the proposed system, this paper applies it into constructing a genic interaction dataset related to Alzheimer’s disease domain, which extracts 3,510 interaction-related sentences by using 140 gene names in the area. In conclusion, the resulting outputs of the case study performed in this paper indicate the fact that the system and process could highly boost the efficiency of the dataset construction in various subfields of biomedical research.
- keywords
- 관계 추출, 학습 집합 구축, 유전자 간 상호 작용, 기계 학습, 텍스트 마이닝, Relation extraction, Dataset construction, Genic interactions, Machine learning, Text mining
참고문헌
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