The paper examined and analyzed the factors affecting TQM in Medical libraries. The questionnaire was used for collecting data and the ANOVA and T-TEST were used for analyzing data. The results showed that librarians positively recognize the need of TQM in Medical libraries. However, the results showed that library system needs to improve the reward system for effective performance of the work. Finally, this study showed that librarians need to be well-qualified person as a professional with the CEO of strong leadership for successful TQM.