This paper describes the major components of ISO/IEC 11179 metadata registry(MDR) standard designed to promote data interoperability between systems, explains and discusses semantic web technology and Web ontology languages initiated by W3C that can be employed to further enhance data interoperability, and finally proposes a framework for a new RDF/OWL-based MDR to convert from the current human-readable MDR to machine-readable MDR. If the new MDR is successful, we might be able to offer a better customized information service to users. The future research will be concerned with evaluating objectively the effectiveness of machine-readable MDR in meeting the needs of real users.