This study aims to investigate the psychological resources that could serve as protective factors against work-family conflict, considering both family-related dynamics and work-related values. To this end, we assessed marital intimacy, work-family conflict, job satisfaction, and work-role salience in a sample of 220 full-time working parents (113 males and 107 females), all of them had at least one child under the age of 13. We analyzed the moderated mediation model by structural equation model using MPlus 8.0. The results demonstrated that higher levels of marital intimacy were associated with increased job satisfaction and reduced work-family conflict. Job satisfaction fully mediated the relationship between marital intimacy and work interference with family (WIF). More importantly, as the significance of one’s work-role increased, the positive relationship between marital intimacy and job satisfaction was strengthened, thereby reducing WIF. Our findings suggest that when individuals place a high value on their work-role, marital intimacy could function as psychological resource to enhance job satisfaction and mitigate work-family conflict. Based on these findings, we discussed the implications of the study and provided recommendations for future research.