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Korean Journal of Psychology: General

Schizophrenia is Associated with Differential Deficit in Executive Function: Integrated analyses of 3 studies

Korean Journal of Psychology: General / Korean Journal of Psychology: General, (P)1229-067X; (E)2734-1127
2009, v.28 no.2, pp.319-342




Abstract

The goal of the present study was to test the hypothesis that schizophrenia is associated with greater deficit in executive function relative to other cognitive functions. To this end, we analyzed schizophrenic and control data from 3 independent studies. We compared performance of schizophrenic and control subjects on 6-paired tests in which one is associated with high involvement of executive function (high EF tests) and the other with low involvement of executive function (low EF tests). There were 3 main findings. First, cognitive deficits of schizophrenic subjects relative to control subjects were greater in high EF tests compared with low EF tests. Second, control subjects showed no significant difference in performance of high versus low EF tests, whereas schizophrenic subjects showed significantly lower performance in high versus low EF tests. Third, there were significant interactions between Group (control, schizophrenia) and Involvement of EF (high, low). These results are consistent with the hypothesis that schizophrenia is associated with differential deficit in executive function. They also suggest that schizophrenia is associated with deficits in frontal-subcortical circuits.

keywords
정신분열병, 인지기능, 관리기능, 실행기능, 전두엽, stroke, dementia, executive function, neuropsychological function, stroke, dementia, executive function, neuropsychological function

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Korean Journal of Psychology: General