Abstract

The purpose of this study was to investigate the effective methods for the treatments of aggressive behavior induced by isolated-rearing. A/J Strain male mice(Mus Musclus)was reared individually after weaning(21± 1 days)to the adult(60±1 days). The auther(Chang, 1984) reported that the isolation syndroms exhibited after isolated-rearing-the increasing of general activity, the hyperaggression to the peer animals, hypersensitivity to the noxious stimuli, and the performance deficit in the learning tasks. Those characteristics were similar to the animals behavior disorders following hippocampus or amygdaloid lesions. Thus, a hypothesis was proposed that isolated-rearing bring up the disfunctions of the a mygdaloid-hippocampal complex(Chang, 1984). Based on the hypothesis, there were adopted, for the amelioration of aggression, diazepam(DZP 1mg/kg)-the mainly activated in the amygdaloid hippocampal complex-treatment(EXP I and H )and rehousing procedure-2hrs per day for 7 days. Aggressive behavior was estimated to tail rattling response(Gandelman, 1972). The major findings were as follows ; 1) Isolated animals revealed higher TR response to the stuffed animal and the peer surrounded by a wire screen than the controls. 2) The treatment of DZP 1mg/kg is effective to reduce isolated animals' TR responses. 3) In the rehousing procedures, the passive opponents(anethesized) were more effective than the actives(normal peer). According to the results of thes study, it was concluded this the antianxiety drug, DZP lmg/kg was effective to reduce the aggresiveness induced isolated-rearing and that the unresponse opponents was effective in the course of rehousing. This result disagrees with Suomi et als(1975)study having emphasied social interaction. It was also suggested that the aggressiveness of the isolated should be elicited by the internal anxiety due to hypersensitivity.