Basal cortisol level and functional asymmetry of the hippocampus

It is well known that extreme stress or continually elevated glucocorticoid levels induce functional deficit and volume reduction in the hippocampus. However, it remains unknown whether stress induces the asymmetry of the hippocampus. To explore the effect of stress on the functional asymmetry of the hippocampus, we investigated an association between basal cortisol levels and the hippocampal asymmetry in the regional cerebral glucose metabolism in 44 right-handed normal elderly female participants (mean age 69.16 ± 4.6). Participants underwent [18F] fluorodeoxyglucose PET scanning during resting state and were assessed basal salivary cortisol levels during daytime. In order to investigate the association between stress related-hippocampal asymmetry and cognitive functions, we compared high-asymmetry group and low-asymmetry group with performance of the Korean-Dementia Rating Scale(K-DRS). We found that diurnal cortisol range was positively correlated with the degree of asymmetry of hippocampal glucose metabolic rates. Also, the K-DRS scores were lower than in the high-asymmetry group than those in the low-asymmetry group. These results suggests that stress may disrupt the bilateral balance in the hippocampal function, which may accelerate cognitive aging.

keywords: Stress, Hippocampus, Cortisol, Cognitive Aging, FDG-PET, 스트레스, 해마, 코티솔, 인지노화, FDG-PET

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Article Contents

Vol.33 No.4

Basal cortisol level and functional asymmetry of the hippocampus

Abstract

Reference

Korean Journal of Psychology: General