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ISSN : 1226-9654

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Vol.14 No.1

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The Effects of Electrical Stimulation to Cerebellar Interpositus Nucleus on the Eyeblink Classical Conditioning

The Korean Journal of Cognitive and Biological Psychology / The Korean Journal of Cognitive and Biological Psychology, (P)1226-9654; (E)2733-466X
2002, v.14 no.1, pp.63-74
Sunyoung Cho (Basic Science Research Institute Chungbuk University)
Hyun-Taek Kim (Department of Psychology Korea University)
Cho, S., & Kim, H. (2002). The Effects of Electrical Stimulation to Cerebellar Interpositus Nucleus on the Eyeblink Classical Conditioning. The Korean Journal of Cognitive and Biological Psychology, 14(1), 63-74.

Abstract

It is well established that the neuronal plasticity in the cerebellar interpositus nucleus(INT) is essential for eyeblink classical conditioning. The current study attempted to combine INT stimulation with the occurrence of learning-related neural activity that normally precedes the behavioral conditioned response. Rabbits were trained with a trace paradigm(300ms tone-CS; 600rns ISI; 100ms air puff-US) that included extracellular stimulation of the INT. The electrical stimulation(ES; 200Hz, 0.1ms pulse width) was administered midway though the trace interval(400ms after CS onset for 50ms). Stimulation intensity was set at 25uA. Extinction training, consisting of tone+ES trials, followed acquisition. Rabbits with INT stimulation acquired conditioned response(CR) to the tone CS very quickly within the first two sessions and showed strong resistance to extinction. The timed INT activation combined with its learning plasticity facilitated learning and maintained the ability of CS to elicit CR. These results could be discussed by the association among three stimuli.

keywords
classical conditioning, cerebellar interpositus nucleus, electrical stimulation, facilitation of Learning

The Korean Journal of Cognitive and Biological Psychology

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