바로가기메뉴

본문 바로가기 주메뉴 바로가기

ACOMS+ 및 학술지 리포지터리 설명회

  • 한국과학기술정보연구원(KISTI) 서울분원 대회의실(별관 3층)
  • 2024년 07월 03일(수) 13:30
 

logo

공포조건화 소거에 따른전두엽-편도체 시냅스 강도의 역동적 조절

Dynamic Regulation of the Synaptic Plasticity in the Prefronto-Amygdala Pathway Following Fear Extinction in Rats

한국심리학회지: 인지 및 생물 / The Korean Journal of Cognitive and Biological Psychology, (P)1226-9654; (E)2733-466X
2013, v.25 no.1, pp.117-128
https://doi.org/10.22172/cogbio.2013.25.1.007
최은주 (고려대학교)
최준식 (고려대학교)
  • 다운로드 수
  • 조회수

Abstract

Fear conditioning, in which a neutral conditioned stimulus (CS) is contingently paired with an aversive unconditioned stimulus (US) and acquires capacity to elicit conditioned response (CR), has been studied extensively to elucidate neural substrate of associative memory. It has been shown that the critical change for the fear memory is stored as a form of modified synaptic response in the lateral nucleus (LA) of the amygdala. On the other hand, extinction, in which the fear CR is reduced as a result of repeated exposure to the CS without the US, has been known to depend on the infralimbic cortex (IL) of the medial prefrontal cortex. However, little is known about the interaction between the IL and LA over the course of extinction process. In the current study, we investigated the synaptic changes in the IL-LA pathway by measuring evoked field potentials (EFPs) before and after fear extinction. Following fear conditioning in which the rats were presented with five parings of the CS and footshock US, they were subjected to two extinction sessions composed of 10 CS-only trials each. In addition, they received a retention test composed of three CS-only presentations. To measure synaptic plasticity, evoked field potentials (EFPs) were recorded in the lateral nucleus of the amygdala (LA) by stimulating the IL, six hours after every session. The recorded EFP was significantly increased after the first extinction but not after the subsequent sessions. These data indicate that dynamic regulation of IL-LA synaptic efficacy underlies the suppression of conditioned fear response following extinction and suggest that consolidation of memory extinction involves changes in other synapses than IL-LA pathway.

keywords
fear, conditioning, extinction, medial prefrontal cortex, evoked field potential, 공포, 조건화, 소거학습, 내측 전전두엽, 유발 장전위

참고문헌

1.

Blair, H. T., Schafe, G. E., Bauer, E. P., Rodrigues, S. M., & LeDoux, J. E. (2001). Synaptic plasticity in the lateral amygdala: a cellular hypothesis of fear conditioning. Learn Mem, 8(5), 229-242.

2.

Ehrlich, I., Humeau, Y., Grenier, F., Ciocchi, S., Herry, C., & Luthi, A. (2009). Amygdala inhibitory circuits and the control of fear memory. Neuron, 62(6), 757-771.

3.

Fanselow, M. S., & LeDoux, J. E. (1999). Why we think plasticity underlying Pavlovian fear conditioning occurs in the basolateral amygdala. Neuron, 23(2), 229-232.

4.

Farinelli, M., Deschaux, O., Hugues, S., Thevenet, A., & Garcia, R. (2006). Hippocampal train stimulation modulates recall of fear extinction independently of prefrontal cortex synaptic plasticity and lesions. Learning & Memory, 13(3), 329- 334.

5.

Herry, C., Ciocchi, S., Senn, V., Demmou, L., Muller, C., & Luthi, A. (2008). Switching on and off fear by distinct neuronal circuits. Nature, 454(7204), 600-606.

6.

Kim, J., Lee, S., Park, K., Hong, I., Song, B., Son, G., Choi, S. (2007). Amygdala depotentiation and fear extinction. Proc Natl Acad Sci U S A, 104(52), 20955-20960.

7.

Kwon, J. T., & Choi, J. S. (2009). Cornering the fear engram: long-term synaptic changes in the lateral nucleus of the amygdala after fear conditioning. J Neurosci, 29(31), 9700- 9703.

8.

Lebron, K., Milad, M. R., & Quirk, G. J. (2004). Delayed recall of fear extinction in rats with lesions of ventral medial prefrontal cortex. Learning & Memory, 11(5), 544-548.

9.

LeDoux, J. E. (2000). Emotion circuits in the brain. Annu Rev Neurosci, 23, 155-184.

10.

McKernan, M. G., & Shinnick-Gallagher, P. (1997). Fear conditioning induces a lasting potentiation of synaptic currents in vitro. Nature, 390(6660), 607-611.

11.

Milad, M. R., & Quirk, G. J. (2002). Neurons in medial prefrontal cortex signal memory for fear extinction. Nature, 420(6911), 70-74.

12.

Morgan, M. A., Romanski, L. M., & LeDoux, J. E. (1993). Extinction of emotional learning: contribution of medial prefrontal cortex. Neurosci Lett, 163(1), 109-113.

13.

Pare, D., & Collins, D. R. (2000). Neuronal correlates of fear in the lateral amygdala: multiple extracellular recordings in conscious cats. J Neurosci, 20(7), 2701-2710.

14.

Park, J., & Choi, J. S. (2010). Long-term synaptic changes in two input pathways into the lateral nucleus of the amygdala underlie fear extinction. Learn Mem, 17(1), 23-34.

15.

Paxinos, G., & Watson, C. (1998). The rat brain in stereotaxic coordinates (Vol. 1). San diego: Academic Press.

16.

Quirk, G. J., Repa, C., & LeDoux, J. E. (1995). Fear conditioning enhances short-latency auditory responses of lateral amygdala neurons: parallel recordings in the freely behaving rat. Neuron, 15(5), 1029-1039.

17.

Quirk, G. J., Russo, G. K., Barron, J. L., & Lebron, K. (2000). The role of ventromedial prefrontal cortex in the recovery of extinguished fear. Journal of Neuroscience, 20(16), 6225-6231.

18.

Repa, J. C., Muller, J., Apergis, J., Desrochers, T. M., Zhou, Y., & LeDoux, J. E. (2001). Two different lateral amygdala cell populations contribute to the initiation and storage of memory. Nat Neurosci, 4(7), 724-731.

19.

Rodrigues, S. M., Schafe, G. E., & LeDoux, J. E. (2004). Molecular mechanisms underlying emotional learning and memory in the lateral amygdala. Neuron, 44(1), 75-91.

20.

Rogan, M. T., Staubli, U. V., & LeDoux, J. E. (1997). Fear conditioning induces associative long-term potentiation in the amygdala. Nature, 390(6660), 604-607.

21.

Rosenkranz, J. A., & Grace, A. A. (2002). Cellular mechanisms of infralimbic and prelimbic prefrontal cortical inhibition and dopaminergic modulation of basolateral amygdala neurons in vivo. J Neurosci, 22(1), 324-337.

22.

Santini, E., Ge, H., Ren, K., Pena de Ortiz, S., & Quirk, G. J. (2004). Consolidation of fear extinction requires protein synthesis in the medial prefrontal cortex. J Neurosci, 24(25), 5704-5710.

한국심리학회지: 인지 및 생물