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  • 한국과학기술정보연구원(KISTI) 서울분원 대회의실(별관 3층)
  • 2024년 07월 03일(수) 13:30
 

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조현병에서 나타나는 주의 기능 장애

Attentional impairment in patients with schizophrenia

한국심리학회지: 인지 및 생물 / The Korean Journal of Cognitive and Biological Psychology, (P)1226-9654; (E)2733-466X
2016, v.28 no.1, pp.99-122
https://doi.org/10.22172/cogbio.2016.28.1.005
김소연 (덕성여자대학교)
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Abstract

Attentional functions are revealed to be impaired in individuals with schizophrenia. However, as attention is a multi-dimensional function, various studies have investigated different types of attentional deficits among patients with schizophrenia. The purpose of this review is to take a comprehensive look at evidence on distinctive aspects of attentional impairments in schizophrenia. Three different domains of attention are of interest in this review: Response inhibition, Selective attention and Conflict resolution, and Attentional shifts and Alerting networks. A number of studies with schizophrenia suggest that the selective attention and conflict resolution are most affected in those patients. The disengagement and attentional reorienting system also seems to be impaired in the patients. In this review, findings from behavior, neuroimaging, and electrophysiological studies are discussed to understand fundamental attentional deficits in patients with schizophrenia. The future direction of studies aiming to elucidate and treat those patients’ attentional mechanism is also discussed.

keywords
Schizophrenia, Response Inhibition, Selective Attention, Conflict Resolution, Attentional Shifting and Alerting networks, 조현병, 반응 억제, 선택적 주의, 인지갈등 해소, 정향주의 시스템

참고문헌

1.

American Psychiatric Association (2013). Diagnostic and Statistical Manual of Mental Disorders 5th Edition. Arlington, VA, American Psychiatric Association.

2.

Abramczyk, R. R., Jordan, D. E., & Hegel, M. (1983). “Reverse” Stroop effect in the performance of schizophrenics. Perceptual and Motor Skills, 56(1), 99-106.

3.

Alain, C., Bernstein, L. J., He, Y., Cortese, F., & Zipursky, R. B. (2002). Visual feature conjunction in patients with schizophrenia: an event-related brain potential study. Schizophrenia Research, 57(1), 69-79.

4.

Backes, V., Kellermann, T., Voss, B., Kramer, J., Depnner, C., Schneider, F., & Habel, U. (2011). Neural correlates of the attention network test in schizophrenia. European Archives of Psychiatry and Clinical Neurosciences, 261 (Suppl 2), S155-S160.

5.

Barch, D. M., Carter, C. S., Perlstein, W., Baird, J., Cohen, J. D., & Schooler, N. (1999a). Increased Stroop facilitation effects in schizophrenia are not due to increased automatic spreading activation. Schizophrenia Research, 39(1), 51-64.

6.

Barch, D. M., Carter, C. S., Hachten, P. C., Usher, M., & Cohen, J. D. (1999b). The “Benefits” of Distractibility: Mechanisms Underlying Increased Stroop Effects in Schizophrenia. Schizophrenia Bulletin, 25(4), 749.

7.

Bertolino, A., Esposito, G., Callicott, J. H., Mattay, V. S., Van Horn, J. D., Frank, J. A., et al (2000). Specific relationship between prefrontal neuronal N- acetylaspartate and activation of the working memory cortical network in schizophrenia. American Journal of Psychiatry, 157, 226-233.

8.

Brébion, G., Villalta-Gil, V., Autonell, J., Cervilla, J., Dolz, M., & Foix, A. (2013). Cognitive correlates of verbal memory and verbal fluency in schizophrenia, and differential effects of various clinical symptoms between male and female patients. Schizophrenia Research, 147, 81-85.

9.

Breton, F., Planté, A., Legauffre, C., Morel, N., Adès, J., Gorwood, P., et al., (2011). The executive control of attention differentiates patients with schizophrenia, their first-degree relatives and healthy controls. Neuropsychologia 49, 203-208.

10.

Carter, C. S., Robertson, L. C., & Nordahl, T. E. (1992). Abnormal processing of irrelevant information in chronic schizophrenia: selective enhancement of Stroop facilitation. Psychiatry Research, 41(2), 137-46.

11.

Carter, C., Robertson, L., Nordahl, T., O'shora- Celaya, L., & Chaderjian, M. (1993). Abnormal processing of irrelevant information in schizophrenia: the role of illness subtype. Psychiatry Research, 48(1), 17-26.

12.

Carter, C. S., Mintun, M., Nichols, T., & Cohen, J. D. (1997). Anterior Cingulate Gyrus Dysfunction and Selective Attention Deficits in Schizophrenia:[15O] H2O PET Study During Single-Trial Stroop Task Performance. American Journal of Psychiatry, 154, 1670-1675.

13.

Castellanos, F. X., Margulies, D. S., Kelly, C., Uddin, L. Q., Ghaffari, M., Kirsch, A., et al. (2008). Cingulate-Precuneus Interactions: A New Locus of Dysfunction in Adult Attention-Deficit/Hyperactivity Disorder. Biological Psychiatry, 63(3), 332-337.

14.

Choi, H-. I., Song, M-. J., Jaekal, E.,, & Choi, K-. H. (2014). Psychosocial Approaches to Negative Symptoms of Schizophrenia: Comprehensive Systematic Review. The Korean Journal of Psychology.: General, 33(4), 875-902.

15.

Corbetta, M., Kincade, J., Ollinger, J., McAvoy, M., & Shulman, G. (2000): Voluntary orienting is dissociated from target detection in human posterior parietal cortex. Nature Neuroscience, 3, 292-297.

16.

Corbetta, M., Kincade, M., Lewis, C., Snyder, A., & Sapir, A. (2005): Neural basis and recovery of spatial attention deficits in spatial neglect. Nature Neuroscience, 8, 1603-1610.

17.

Corcoran, R., Mercer, G., & Frith, C. D. (1995). Schizophrenia, symptomatology and social inference: investigating “theory of mind” in people with schizophrenia. Schizophrenia Research, 17(1), 5-13.

18.

Daban, C., Krebs, M. O., Bourdel, M. C., Willard, D., Loo, H., Olié, J. P., et al. (2004). Effects of atypical neuroleptics on alertness and visual orienting in stabilized schizophrenic patients: a preliminary study. International Journal of Neuropsychopharmacology, 7, 255-263.

19.

Dibben, C. R. M., Rice, C., Laws, K., & McKenna, P. J. (2009). Is executive impairment associated with schizophrenic syndromes? A meta-analysis. Psychological Medicine, 39, 381-392.

20.

Elvevag, B., & Goldberg, T. E. (2000). Cognitive impairment in schizophrenia is the core of the disorder. Crit Rev Neurobiology, 14(1), 1-21.

21.

Everett, J. P., Laplante, L., Ps, B., & Thomas, J. (1989). The Selective Attention Deficit in Schizophrenia: Limited Resources or Cognitive Fatigue? The Journal of Nervous and Mental Disease, 177(12), 735.

22.

Erikson, M. A., Hahn, B., Leonard, C. J., Robinson, B., Gray, B., Luck, S. J., & Gold, J., (2014). Impaired Working Memory Capacity Is Not Caused by Failures of Selective Attention in Schizophrenia. Schizophrenia Bulletin. 1-8.

23.

Fioravanti, M., Bianchi, V., & Cinti, M. L. (2012). Cognitive deficits in schizophrenia: an updated metanalysis of the scientific evidence. BMC Psychiatry, 12:64, 1-20.

24.

Folstein, J. R., & Van Petten, C. (2008). Influence of cognitive control and mismatch on the N2 component of the ERP: A review. Psychophysiology, 45(1):152-170.

25.

Ford, J. M., Gray, M., Whitfield, S. L., Turken, A. U., Glover, G., Faustman, W. O., et al. (2004). Acquiring and inhibiting prepotent responses in schizophrenia: Event-related brain potentials and functional magnetic resonance imaging. Archives of General Psychiatry, 61, 1119-1129.

26.

Fuller, R. L., Luck, S. J., Braun, E. L., Robinson, B. M., McMahon, R. P., & Gold, J. M. (2006). Impaired control of visual attention in schizophrenia. Journal of Abnormal Psychology, 115(2), 266-275.

27.

Gold, J. T., Randolph, C., Coppola, R., Carpenter, C. J., Goldberg, T. E., & Weinberger, D. R. (1992). Visual orienting in schizophrenia. Schizophrenia Research, 7, 203-209.

28.

Gold, J. M., Fuller, R. L., Robinson, B. M., Braun, E. L., & Luck, S. J. (2007). Impaired top-down control of visual search in schizophrenia. Schizophrenia Research, 94(1-3), 148-155.

29.

Gooding, D. C., Braun, J. G., & Studer, J. A. (2006). Attentional network task performance in patients with schizophrenia- spectrum disorders: Evidence of a specific deficit. Schizophrenia Research, 88(1-3), 169- 178.

30.

Groom, M. J., Jackson, G. M., Calton, T. G., Andrews H. K., Bates, A. T., & Liddle, P. F. (2008). Cognitive deficits in early-onset schizophrenia spectrum patients and their non-psychotic siblings: A comparison with ADHD. Schizophrenia Research, 99, 85-95.

31.

Gur, R. E., Turetsky, B. I., Loughead, J., Snyder, W., Kohler, C., Elliott, M., et al. (2007). Visual Attention Circuitry in Schizophrenia Investigated With Oddball Event-Related Functional Magnetic Resonance Imaging. American Journal of Psychiatry, 164(3), 442-449.

32.

Gyo, S. S., & Kim, H. (2004). Frontal-executive Functions in Schizophrenia Patients. The Korean Journal of Psychology: General, 23(2), 23-43.

33.

Heinrichs, R. W., & Zakzanis, K. K. (1998). Neurocognitive deficit in schizophrenia: a quantitative review of the evidence. Neuropsychology, 12(3), 426-445.

34.

Henik, A., Carter, C. S., Salo, R., Chaderjian, M., Kraft, L., Nordahl, T. E., et al. (2002). Attentional control and word inhibition in schizophrenia. Psychiatry Research, 110(2), 137- 149.

35.

Jentsch, J. D., & Roth, R. H. (1999). The neuropsychopharmacology of phencyclidine: from NMDA receptor hypofunction to the dopamine hypothesis of schizophrenia. Neuropsychopharmacology, 20, 201-225.

36.

Jung, W. H., Jang, J. H., Shin, N. Y., Kim, S. N., Choi, C. H., An, S. K., et al. (2012). Regional brain atrophy and functional disconnection in Broca's area in individuals at ultra-high risk for psychosis and schizophrenia. PloS One 7:e51975.

37.

Kang S. S., Dionisio, D. P., & Sponheim, S. R. (2011). Abnormal mechanisms of antisaccade generation in schizophrenia patients and unaffected biological relatives of schizophrenia patients. Psychophysiology, 48, 350-361.

38.

Kiehl, K. A., Smith, A. M., Hare, R. D., & Liddle, P. F. (2000). An event-related potential investigation of response inhibition in schizophrenia and psychopathy. Biological Psychiatry, 48(3), 210-221.

39.

Kim, J., Park, S., & Blake, R. (2011). Perception of biological motion in schizophrenia and healthy individuals: A behavioral and fMRI study. PLos One, 6: e19971.

40.

Kim, J. (2014). Abnormal frontal activation during the perception of biological motion in patients with schizophrenia. The Korean Journal of Cognitive and Biological Psychology, 26(4), 233-253.

41.

Kim, S. (2014). Attentional Functions and Dysfunctions in ADHD. The Korean Journal of Cognitive and Biological Psychology, 26(2), 67-94.

42.

Koelkebeck, K., Pedersen, A., Suslow, T., Kueppers, K. A., Arolt, V., & Ohrmann, P. (2010). Theory of Mind in first-episode schizophrenia patients: Correlations with cognition and personality traits. Schizophrenia Research, 119, 115-123.

43.

Ko, Y-.H., & Oh, S-.W. (2012). Comparison of Emotional Experience and Emotional Expressivity of Patients with Schizophrenia. The Korean Journal of Psychology: Clinical, 23(2), 23-43.

44.

Lewis, D. A., Pierri, J. N., Volk, D. W., Melchitzky, D. S., Woo, T. U. (1999). Altered GABA neurotransmission and prefrontal cortical dysfunction in schizophrenia. Biological Psychiatry 46, 616-626.

45.

Luck, S. J., & Gold, J. M. (2008). The Construct of Attention in Schizophrenia. Biological Psychiatry, 64(1), 34-39.

46.

Luck, S. J., Ford, J. M., Sarter, M., & Lustig, C. (2012). CNTRICS Final Biomarker Selection: Control of Attention. Schizophrenia Bulletin, 38(1). 53-61.

47.

Lustig, C., Kozak, R., Sarter, M., Young, J. W., & Robbins, T. W. (2013). CNTRICS final animal model task selection: Control of attention. Neuroscience and Biobehavioral Reviews, 37, 2099-2110.

48.

Mathalon D. H., & Ford J. M., Pfefferbaum A. (2000). Trait and state aspects of P300 amplitude reduction in schizophrenia: a retrospective longitudinal study. Biological Psychiatry, 47, 434-449.

49.

Maruff, P., Hay, D., Malone, V., & Currie, J. (1995). Asymmetries in the covert orienting of visual spatial attention in schizophrenia. Neuropsychologia, 33(10), 1205-1223.

50.

Maruff, P., Pantelis, C., Danckert, J., Smith, D., & Currie, J. (1996). Deficits in the endogenous redirection of covert visual attention in chronic schizophrenia. Neuropsychologia, 34(11), 1079-1084.

51.

Maruff, P., Danckert, J., Pantelis, C., & Currie, J. (1998). Saccadic and attentional abnormalities in patients with schizophrenia. Psychological Medicine, 28(5), 1091-1100.

52.

Mori, S., Tanaka, G., Ayaka, Y., Michitsuji, S., Niwa, H., Uemura, M., et al. (1996). Preattentive and focal attentional processes in schizophrenia: a visual search study. Schizophrenia Research, 22(1), 69-76.

53.

Nestor, P. G., Faux, S. F., McCarley, R. W., Penhune, V., Shenton, M. E., & Pollak, S. (1992). Attentional cues in chronic schizophrenia: abnormal disengagement of attention. Journal of Abnormal Psychology, 101(4), 682-689.

54.

Neuhaus, A. H., Koehler, S., Opgen-Rhein, C., Urbanek, C., Hahn, E., & Dettling, M. (2007). Selective anterior cingulate cortex deficit during conflict solution in schizophrenia: An event-related potential study. Journal of Psychiatric Research, 41(8), 635-644.

55.

Nuechterlein, K. H., Luck, S. J., Lustig, C., Sarter, M. (2009). CNTRICS Final Task Selection: Control of Attention. Schizophrenia Bulletin, 35(1), 182-196.

56.

Opgen-Rhein C., Neuhaus, A. H., Urbanek, C., Hahn., E., Sander, T., Dettling, M. (2008). Executive Attention in Schizophrenic Males and the Impact of COMT Val108/158Met Genotype on Performance on the Attention Network. Schizophrenia Bulletin, 34(6). 1231- 1239.

57.

Orellana G., Slachevsky, A., Peña, M. (2012). Executive attention impairment in first- episode schizophrenia. BMC Psychiatry, 12(154), 1-9.

58.

Pallanti, S., Castellini, G., Chamberlain, S. R., Quercioli, L., Zaccara, G., Fineberg, N. A. (2009). Cognitive event-related potentials differentiate schizophrenia with obsessivecompulsive disorder (schizo-OCD) from OCD and schizophrenia without OC symptoms. Psychiatry Research, 170, 52-60.

59.

Penn, D. L., Corrigan, P. W., Bentall, R. P., Racenstein, J. M., & Newman, L. (1997). Social cognition in schizophrenia. Psychological Bulletin, 121, 114-132.

60.

Posner, M. I. (1980). Orienting of attention. The Quarterly Journal of Experimental Psychology, 32(1), 3-25.

61.

Posner, M. I., Early, T. S., Reiman, E., Pardo, P. J., & Dhawan, M. (1988). Asymmetries in hemispheric control of attention in schizophrenia. Archives of General Psychiatry, 45(9), 814-821

62.

Rubia, K., Russell, T., Bullmore, E. T., Soni, W., Brammer, M. J., Simmons, A., et al. (2001). An fMRI study of reduced left prefrontal activation in schizophrenia during normal inhibitory function. Schizophrenia Research, 52(1-2), 47-55.

63.

Sambataro, F., Mattay, V. S., Thurin, K., Safrin, M., Rasetti, R., Blasi, G., et. al. (2013). Altered Cerebral Response During Cognitive Control: A Potential Indicator of Genetic Liability for Schizophrenia. Neuropsychopharmacology, 38, 846-853.

64.

Singh, F., Pineda, J., & Cadenhead, K. S. (2011). Association of impaired EEG mu wave suppression, negative symptoms and social functioning in biological motion processing in first episode of psychosis. Schizophrenia Research, 130, 182-186.

65.

Solanto, M. V. (1998). Neuropsychopharmacological mechanisms of stimulant drug action in attention-deficit hyperactivity disorder: a review and integration. Behavioural Brain Research, 94(1), 127-152.

66.

Strauss, M. E., Novakovic, T., Tien, A. Y., Bylsma, F., & Pearlson, G. D. (1991). Disengagement of attention in schizophrenia. Psychiatry Research, 37(2), 139-46.

67.

Tanaka, G., Mori, S., Inadomi, H., Hamada, Y., Ohta, Y., & Ozawa, H. (2007). Clear distinction between preattentive and attentive process in schizophrenia by visual search performance. Psychiatry Research, 149(1-3), 25-31.

68.

Taniguchi, K., Sumitani, S., Watanabe, Y., Akiyama, M., & Ohmori, T. (2012). Multi-channel near-infrared spectroscopy reveals reduced prefrontal activation in schizophrenia patients during performance of the kana Stroop task. Journal of Medical Investigation, 59(1-2), 45-52.

69.

Taylor, S. F., Kornblum, S., & Tandon, R. (1996). Facilitation and interference of selective attention in schizophrenia. Journal of Psychiatric Research, 30(4), 251-259.

70.

Thermenos H. W., Keshavan M. S., Juelich R. J., Molokotos E., Whitfield-Gabrieli S., Brent B. K., et al. (2013): A review of neuroimaging studies of young relatives of individuals with schizophrenia: a developmental perspective from schizotaxia to schizophrenia. American Journal of Medical Genetics Part B, 162B, 604-635.

71.

Thermenos H. W., Whitfield-Gabrieli S., Seidman L. J., Kuperberg G., Juelich R. J., Divatia S., et al. (2013). Altered language network activity in young people at familial high-risk for schizophrenia. Schizophrenia Research, 151, 229-237.

72.

Thiel, C., Zilles, K., & Fink, G. (2004). Cerebral correlates of alerting, orienting and reorienting of visuospatial attention: an event-related fMRI study. Neuroimage, 21, 318-328.

73.

Treisman, A., & Gelade, G. (1980). A feature- integration theory of attention. Cognitive Psychology, 12(1), 97-136.

74.

Turetsky, B. I., Colbath, E. A., & Gur, R. E. (1998). P300 subcomponent abnormalitiesin schizophrenia, I: physiological evidence for gender and subtype specific differences in regional pathology. Biological Psychiatry, 43, 84-96.

75.

Verbruggen, F., & Logan, G. (2008). Response inhibition in the stop-signal paradigm. Trends in Cognitive Science, 12(11), 418-424.

76.

Wagner G., De la Cruz, F., Schachtzabel, C., Gu¨llmar, D., Schultz, C. C., Schl€osser, R. G., et. al. (2015). Structural and functional dysconnectivity of the fronto-thalamic system in schizophrenia: A DCM-DTI study. Cortex, 66, 35-45.

77.

Wang, K., Fan, J., Dong, Y., Wang, C., Lee, T. M. C., & Posner, M. I. (2005). Selective impairment of attentional networks of orienting and executive control in schizophrenia. Schizophrenia Research, 78(2-3), 235-241.

78.

Weisbrod, M., Hill, H., Niethammer, R., & Sauer, H. (1999). Genetic influence on auditory information processing in schizophrenia: P300 in monozygotic twins. Biological Psychiatry, 46(5), 721-725.

79.

Weiss, E. M., Siedentopf, C., Golaszewski, S., Mottaghy, F. M., Hofer, A., Kremser, C., et al. (2007). Brain activation patterns during a selective attention test—a functional MRI study in healthy volunteers and unmedicated patients during an acute episode of schizophrenia. Psychiatry Research: Neuroimaging, 154(1), 31-40.

80.

World Health Organization (2008). The Global Burden of Disease. Geneva, Switzerland, World Health Organization.

81.

Yantis S., Schwarzbach J., Serences, J., Carlson, R., Steinmetz, M., & Pekar, J. (2002): Transient neural activity in human parietal cortex during spatial attention shifts. Nature Neuroscience, 5, 995-1002

82.

Yücel, M., Pantelis, C., Stuart, G. W., Wood, S. J., Maruff, P., Velakoulis. D., et al. (2014). Anterior Cingulate Activation During Stroop Task Performance: A PET to MRI Coregistration Study of Individual Patients With Schizophrenia. American Journal of Psychiatry, 159, 251-254.

83.

Zajenkowski, M., Styla, R., & Jedrasik-Styla, M. (2015). Task related stress and cognitive control in patients with schizophrenia. Psychiatria Polaska, 49(2), 337-347.

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