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ISSN : 1226-9654

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An experimental study on the mechanism of stress-induced stomach ulcer: Effects of Dopaminergic Substances on the Stress-induced Gastric Ulcers in Isolated Mice

The Korean Journal of Cognitive and Biological Psychology / The Korean Journal of Cognitive and Biological Psychology, (P)1226-9654; (E)2733-466X
1991, v.3, pp.11-21
Hyoun-Kab Chang (Yeungnam University)
Soon-Kwon Park (Yeungnam University)
Sung-Gun Kang (Yeungnam University)
Chang, H., Park, S., & Kang, S. (1991). An experimental study on the mechanism of stress-induced stomach ulcer: Effects of Dopaminergic Substances on the Stress-induced Gastric Ulcers in Isolated Mice. The Korean Journal of Cognitive and Biological Psychology, 3, 11-21.

Abstract

The one purpose of present study was to examine whether dopamine system is involved in the stress-induced stomach ulceration in mice and the other purpose was to show how attenuation of ulcer by isolation-rearing relates to dopamine system, L-dopa treated animals revealed significantly lower ulceration score than that of saline treatment animals, whereas haloperidol treated animals showed higher ulceration score than saline group in both isolation-reared animals and peer-reared animals. Compared with peer-rearing group, isolation-rearing reduced significantly the development of ulcer in L-dopa, saline, and haloperidol treatment. There was a similar ulceration score between L-dopa treated peer group and haloperidol treated isolation group. The results support our previous findings that catecholamine activity is elevated abnormally by isolation-rearing.

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The Korean Journal of Cognitive and Biological Psychology

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