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ISSN : 1226-9654

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Vol.3

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Effects of Yohimbine Administration after Central Amygdaloid Lesion on Fear-Potentiated Startle Response in Rats

The Korean Journal of Cognitive and Biological Psychology / The Korean Journal of Cognitive and Biological Psychology, (P)1226-9654; (E)2733-466X
1991, v.3, pp.124-133
Seung-Hee Lee (Korea University)
Ki-Suk Kim (Korea University)
Lee, S., & Kim, K. (1991). Effects of Yohimbine Administration after Central Amygdaloid Lesion on Fear-Potentiated Startle Response in Rats. The Korean Journal of Cognitive and Biological Psychology, 3, 124-133.

Abstract

The present study demonstrated that fear-potentiated startle is blocked by bilateral lesions of the amygdala and that yohimbine increases fear-potentiated startle response. But yohimbine administration after central amygdaloid lesion didn't increase potentiated startle. These results were consistent with the hypothesis that amygdala is involved in fear conditioning because potentiated startle is a measure of conditioned fear. 26 rats were given 10 light-shock pairings on two successive days. On the next day, 13 rats received bilateral radio frequency(RF) lesion of the central nucleus of the amygdala. The rest of the rats were tested for potentiated startle(increased acoustic startle in the presence of the light previously paired with shock). Yohimbine was administered to 7 rats in the operated group and not to the other 6 rats. Yohimbine administration after central amygdaloid lesion didn't increase potentiated startle. Results support that the amygdala(and perhaps more specifically the central nucleus), which has been implicated in the modulation of a number of fear conditioning paradigms, is involved for performance of the potentiated startle response.

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The Korean Journal of Cognitive and Biological Psychology

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