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ISSN : 1226-9654

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Effects of Electrolytic and Kainic Acid Lesions of the Central Nucleus of the Amygdala on the Fear-Potentiated Startle Responses

The Korean Journal of Cognitive and Biological Psychology / The Korean Journal of Cognitive and Biological Psychology, (P)1226-9654; (E)2733-466X
1992, v.4, pp.108-121
Jung-Soo Han (Korea University)
Si-Hyun Kim (Korea University)
Ki-Suk Kim (Korea University)
Han, J., Kim, S., & Kim, K. (1992). Effects of Electrolytic and Kainic Acid Lesions of the Central Nucleus of the Amygdala on the Fear-Potentiated Startle Responses. The Korean Journal of Cognitive and Biological Psychology, 4, 108-121.

Abstract

Of several amygdaloid nucleus, the central amygdaloid nucleus seems to be related to the expression of fear. This experiment is to examine effects of the central nucleus of amygdala on the fear-potentiated startle responses. In experiment 1, monopolar tungsten for lesioning were chronically implanted into the central amygdaloid nucleus in rats. After 7 days, rats received two conditioning sessions on consecutive day, each session consists of 10 light-footshock pairing(light of 8w incandescent bulbs, 3700msec: footshock of 1.0mA, 500msec: ITI of 4min). After the conditioning, electrolytic lesion(2.0mA, 10sec) was administered to the central nucleus. One day or seven days later, rats were tested for conditioned fear by comparing the magnitude of the startle reflex to a noise burst presented either alone or in the presence of the previously fear-conditioned light. Results were that the lesioned animals showed no fear-potentiated startle responses. In experiment 2, using kainic acid(0.1㎍/0.2㎕), we lesioned cell bodies without damaging any axons after the conditioning. Results showed that animals lesioned with the kainic acid did not showed potentiated startle responses to the conditioned stimuli. Taken together, it may be said that the intrinsic elements of central amygdaloid nucleus are involved in the expression of fear.

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The Korean Journal of Cognitive and Biological Psychology

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