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ISSN : 1226-9654

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Extinction Effects of Conditioned Nictitating Membrane Response by Inferior Olive Lesion

The Korean Journal of Cognitive and Biological Psychology / The Korean Journal of Cognitive and Biological Psychology, (P)1226-9654; (E)2733-466X
1989, v.1, pp.40-47
Young-Hwa Yun (Korea University)
Ki-Suk Kim (Korea University)
Yun, Y., & Kim, K. (1989). Extinction Effects of Conditioned Nictitating Membrane Response by Inferior Olive Lesion. The Korean Journal of Cognitive and Biological Psychology, 1, 40-47.

Abstract

Classical conditioning of the nictitating membrane response(NMR) of rabbits has been shown to be critically dependent upon the cerebellum. The rostro-medial portions of the inferior olive(rmIO) receive facial somatosensory information and relay it to the cerebellum. The present experiment was conducted to answer the question of whether inferior olive is part of a neural circuit which provides unconditioned(US) information to the cerebellum during NMR conditioning. After lesion electrodes were implanted in the inferior olive of the rabbits, then they were conditioned by pairing tone as conditioned stimulus(CS) and periorbital shock as US. Lesions were then made through the chronic electrode and reconditioning was attempted from the next day on. The lesions of the rmIO caused a previously conditioned NMR to decrease slowly in CR percentile even with continued CS-US pairing. This phenomenon is similar to extinction of the learned response. The lesion had no effect on the unconditioned response. Lesions of the lateral portions to and dorsal portions above the IO did not affect the conditioned NMR. These results are consistent with the hypothesis that the cerebellum is a critically important neuronal structure of the NMR learning and US information is conveyed to the cerebellum by the climbing fiber from the inferior olive.

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Submission Date
1989-10-20
Revised Date
1989-11-05
Accepted Date

The Korean Journal of Cognitive and Biological Psychology

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