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ISSN : 1226-9654

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Vol.11 No.1

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Effects of kainic acid lesion of the red nucleus on neuronal activities of the hippocampus and cerebellum during classical conditioning of nictitating membrane response in the rabbits

The Korean Journal of Cognitive and Biological Psychology / The Korean Journal of Cognitive and Biological Psychology, (P)1226-9654; (E)2733-466X
1999, v.11 no.1, pp.59-70
Soyoung Kwack (Dept. of Psychology, Korea University)
Jaewook Ryou (Dept. of Psychology, Korea University)
Hyuntaek Kim (Dept. of Psychology, Korea University)
Kwack, S., Ryou, J., & Kim, H. (1999). Effects of kainic acid lesion of the red nucleus on neuronal activities of the hippocampus and cerebellum during classical conditioning of nictitating membrane response in the rabbits. The Korean Journal of Cognitive and Biological Psychology, 11(1), 59-70.

Abstract

The red nucleus(RN) of the rabbits was destroyed with injection of kainic acid, and the conditioned nictitating membrane response was examined using a delayed paradigm with 450msec ISI, while the multiple neuronal activities were simultaneously recorded from both the cerebellar interpositus nucleus(INT) and the hippocampus(HIP). The RN lesion blocked the development of learning-related neuronal activities in the HIP as well as the aquisition of the conditioned response(CR). Animals with RN lesion also showed the retardation of development of learning-related neuronal activities in the INT compared to control animals, suggesting that the RN lesion affected the formation of memory trace in the INT. It is thought that, with a relatively long ISI, the information about the performance is required to establish successful learning. Similarly, according to a computational approach, CR information from the RN to the INT enables error-correction. Thus, based on results obtained in the current study we propose that RN is more than a simple relay station in the motor command pathway and it actively participates in establishment of the adaptive CR.

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The Korean Journal of Cognitive and Biological Psychology

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