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ISSN : 1226-9654

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Vol.14 No.1

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Nitric Oxide Synthase Inhibitor Facilitates Functional Recovery after Sciatic Nerve Injury

The Korean Journal of Cognitive and Biological Psychology / The Korean Journal of Cognitive and Biological Psychology, (P)1226-9654; (E)2733-466X
2002, v.14 no.1, pp.29-37
Bae Hwan Lee (Medical Research Center, Brain Research Institute, BK21 Project for Medical Science, Yonsei University College of Medicine)
Ran Won (Graduate School of East-West Medical Science, Kyunghee University)
Eun Joo Kim (Medical Research Center, Brain Research Institute, BK21 Project for Medical Science, Yonsei University College of Medicine)
Hye Yoon Nahm (Medical Research Center, Brain Research Institute, BK21 Project for Medical Science, Yonsei University College of Medicine)
Eun Jung Kim (Medical Research Center, Brain Research Institute, BK21 Project for Medical Science, Yonsei University College of Medicine)
Yong Gou Park (Medical Research Center, Brain Research Institute, BK21 Project for Medical Science, Yonsei University College of Medicine)
Lee, B. H., Won, R., Kim, E. J., Nahm, H. Y., Kim, E. J., & Park, Y. G. (2002). Nitric Oxide Synthase Inhibitor Facilitates Functional Recovery after Sciatic Nerve Injury. The Korean Journal of Cognitive and Biological Psychology, 14(1), 29-37.

Abstract

It has been shown that nitric oxide(NO) is a mediator of nerve injury or the physiological response to injury. The present study was conducted to determine whether NO synthase(NOS) inhibitor enhances functional recovery after nerve injury or not. Under pentobarbital anesthesia, male Sprague-Dawley rats were subjected to one of four different types of sciatic nerve injury (crush, cut, ligation, and sham injury models). The rats received i.p. injections of N<sup>&#x03C9;</sup>-nitro- L-arginine methyl ester(L-NAME), a NOS inhibitor, for ten days from the day of surgery. Twenty five days after injury, the rats were anaesthetized with urethane and the compound muscle action potentials(CMAPs) were recorded following sciatic nerve stimulation. L-NAME significantly shortened the latencies of the CMAPs in crush injury model compared to the vehicle treated rats. In the case of cut or ligation injury model, L-NAME tended to shorten the latencies but the differences between L-NAME and vehicle treated rats were not statistically significant. These results suggest that L-NAME facilitates functional recovery after sciatic nerve injury.

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The Korean Journal of Cognitive and Biological Psychology

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