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ISSN : 1226-9654

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Vol.14 No.1

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Interaction between opioid and NMDA systems involved in the modulation of neuropathic pain

The Korean Journal of Cognitive and Biological Psychology / The Korean Journal of Cognitive and Biological Psychology, (P)1226-9654; (E)2733-466X
2002, v.14 no.1, pp.47-61
Ran Won (Medical Research Center, Yonsei University College of Medicine)
Jin Sun Yoon (Medical Research Center, Yonsei University College of Medicine)
Se Jung Jung (Medical Research Center, Yonsei University College of Medicine)
Kyung Hee Lee (Medical Research Center, Yonsei University College of Medicine)
Jin Hwan Oh (Medical Research Center, Yonsei University College of Medicine)
Jin-Hun Sohn (Department of Psychology, Chungnam National University)
Bae Hwan Lee (Medical Research Center, Yonsei University College of Medicine)
Won, R., Yoon, J. S., Jung, S. J., Lee, K. H., Oh, J. H., Sohn, J., & Lee, B. H. (2002). Interaction between opioid and NMDA systems involved in the modulation of neuropathic pain. The Korean Journal of Cognitive and Biological Psychology, 14(1), 47-61.

Abstract

It is very important to develop effective method to relieve neuropathic pain which may be produced by nerve or tissue injury. This study was conducted to determine interaction between opioid and NMDA systems in the modulation of sympathetically independent neuropathic pain. Under halothane anesthesia, the tibial and sural nerves of male Sprague-Dawley rats were ligated and cut. Fourteen days after injury, the rats were reanesthesized by urethane and subjected to iontophoretic experiment. Opioid agonists such as DAMGO (µ), DALDA (δ), and bremazocine (K) were ejected microiontophoretically. MK-801, an NMDA antagonist, was injected intravenously. Microiontophoretically ejected DAMGO more robustly inhibited the responses of dorsal horn neurons to external stimulation compared to DALDA or bremazocine. Furthermore, iontophoretically ejected DAMGO enhanced the inhibitory effects of intravenously injected MK-801. The results suggest that opioid system may interact with NMDA system in modulation of neuropathic pain, depending on receptor subtypes.

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The Korean Journal of Cognitive and Biological Psychology

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