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ISSN : 1226-9654

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Effects of Haloperidol and L - dopa on the Stress-induced Ulceration in Mice

The Korean Journal of Cognitive and Biological Psychology / The Korean Journal of Cognitive and Biological Psychology, (P)1226-9654; (E)2733-466X
1990, v.2, pp.60-68
Hyoun-Kab Chang (Yeungnam University)
Sung-Gun Kang (Yeungnam University)
Joong-Cheol Bae (Yeungnam University)
Chang, H., Kang, S., & Bae, J. (1990). Effects of Haloperidol and L - dopa on the Stress-induced Ulceration in Mice. The Korean Journal of Cognitive and Biological Psychology, 2, 60-68.

Abstract

The purpose of present sutdy investigated the effect of haloperidol and L-dopa on the gastric ulcerationin in mice, 30 Male mice were separated from their own litters on the weaning (21±1 days) and then reared in group for 60 days. The mice were randomly allocated into three groups: 1) Saline group. Haloperidol(1mg/kg) group, L-dopa(150mg/kg) group. They were immobilized individually in supine-restraint devicers at 4℃, and after 1hr of cold restraint and 1½hr postrestraint rest period. The mice were sacrificed with an overdose Chloral Hydrate(400mg/kg, ip). The stomachs were then dissected out, cut alling the greater curvature, washed in cold water and examined micrescopically(×100) for gastric lesions. Histological samples were assessors in four scales. The results obtained were as follow; 1) L-dopa treated group revealed significantly lower stress-induced ulceration score than saline treatment group.

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The Korean Journal of Cognitive and Biological Psychology

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