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Effects of Amygdala Inactivation on the Expression of Conditioned Fear and the Performance of Active Avoidance

The Korean Journal of Cognitive and Biological Psychology / The Korean Journal of Cognitive and Biological Psychology, (P)1226-9654; (E)2733-466X
2008, v.20 no.4, pp.303-320
https://doi.org/10.22172/cogbio.2008.20.4.006



Abstract

This study examined the effects of amygdala inactivation on the expression of conditioned fear and the performance of active avoidance. Rats, with chronic cannulae placed bilaterally in the amygdala, were given 30 active avoidance training trials for 3 days and 1 or 2 days later tested for conditioned fear and active avoidance immediately after muscimol or buffer injection into the amygdala. As a result, activity to the CS in the amygdala inactivation group was larger than that of controls while performance of active avoidance was not different. In other words, amygdala inactivation impaired expression of conditioned fear but not active avoidance response. These findings suggest that both memory storage and memory modulation, different view about the role of amygdala, are correct in part and the discrepancy between the two stems from the task difference in part. Thus, amygdala seems to be the locus of CS-US association and, at the same time, modulates memory consolidation in other brain regions. It means that neural mechanisms for the expression of conditioned fear and the performance of active avoidance are not the same.

keywords
Active avoidance, Amygdala inactivation, Conditioned fear, Memory modulation, Memory storage, Task difference, 과제차이, 공포조건형성, 기억조절, 능동회피학습, 조건공포, 편도체, muscimol

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The Korean Journal of Cognitive and Biological Psychology