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ACOMS+ 및 학술지 리포지터리 설명회

  • 한국과학기술정보연구원(KISTI) 서울분원 대회의실(별관 3층)
  • 2024년 07월 03일(수) 13:30
 

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편도체 기저외측핵의 뮤 수용기 수의 하향조절은 항유해 효과를 방해한다

Down Regulating Mu Receptors in the Basolateral Complex of Amygdala Prevents Antinociception in the Rat

한국심리학회지: 인지 및 생물 / The Korean Journal of Cognitive and Biological Psychology, (P)1226-9654; (E)2733-466X
2008, v.20 no.4, pp.285-301
https://doi.org/10.22172/cogbio.2008.20.4.005
신맹식 (중앙대학교)
데이빗 베일리 (위스콘신 대학교-밀워키 심리학과)
세실리아 힐러드 (위스콘신 의과대학 약리학 및 중독과)
프레드 헬름스테터 (위스콘신 대학교-밀워키 심리학과)

Abstract

Data from our laboratory indicate that application of the mu agonist DAMGO into the basolateral complex of amygdala (BLA) suppresses tail flick reflexes in anesthetized rats. This DAMGO-induced antinociception can be blocked by pretreatment of the BLA with the nonselective opioid antagonist naltrexone, the mu opioid antagonist β-FNA, or the G protein inhibitor pertussis toxin, suggesting that DAMGO's interaction with G protein-coupled mu receptors in the BLA leads to production of antinociception. The present study employing the gene control strategy was conducted to further investigate the direct action of DAMGO on the mu receptors in the BLA. Intra-BLA application of antisense oligodeoxynucleotides (ODN) against mu receptors blocked antinociception following intra-BLA injection of DAMGO. The amount of [3H]-DAMGO binding to mu receptors in the amygdala was also reduced in the antisense ODN-pretreated rats. These data confirm the idea that antinociception induced by DAMGO in the BLA results from a direct interaction of DAMGO with mu receptors in the amygdala.

keywords
뮤 수용기, 편도체, 꼬리회피반사, 유전자 조절, 안티센스 올리고디옥시뉴클리오티드, 방사성 DAMGO 결합, Mu receptor, Amygdala, Tail flick, Gene control, Antisense oligodeoxynucleotides (ODN), [3H]-DAMGO binding

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한국심리학회지: 인지 및 생물