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Neurocognitive effects of stress on the hippocampus: a systems level analysis

The Korean Journal of Cognitive and Biological Psychology / The Korean Journal of Cognitive and Biological Psychology, (P)1226-9654; (E)2733-466X
2012, v.24 no.1, pp.65-88
https://doi.org/10.22172/cogbio.2012.24.1.004
(University of Washington)
(University of Washington)

Abstract

In modern and hectic society, we constantly encounter stressful events in daily life. Although stress response serves a fundamental, protective role in our lives, uncontrollable stress has been shown to cause behavioral and cognitive impairments that can contribute to various psychiatric conditions such as anxiety disorders. In particular, considerable evidence indicates that uncontrollable stress has detrimental effects on the hippocampus, a medial temporal lobe structure crucial for memory. This review will highlight a systems-level model of stress based on three psychological constructs (excitability, aversiveness, and uncontrollability) and underlying biological substrates (stress hormones, amygdala, and medial prefrontal cortex), and how it may provide a conceptual scaffold to structure and further our understanding of stress effects on the hippocampus, namely by focusing on spatial memory and place cells.

keywords
stress, hippocampus, glucocorticoids, amygdala, prefrontal cortex, spatial memory, place cells, 스트레스, 해마, glucocorticoids, 편도체, 전전두피질, 공간기억, 장소세포

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