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The Effects of Categorical Relationship Between Memory Items on Hippocampal Activation in a Long-term Associative Memory Task

The Korean Journal of Cognitive and Biological Psychology / The Korean Journal of Cognitive and Biological Psychology, (P)1226-9654; (E)2733-466X
2012, v.24 no.4, pp.453-470
https://doi.org/10.22172/cogbio.2012.24.4.008




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Abstract

An event-related functional magnetic resonance imaging (fMRI) experiment was conducted to test the effects of categorical relationship between memory items on hippocampal activation during encoding and retrieval of long-term associative memory. The experiment alternated a learning and a test phase eight times in the scanner. Each phase presented 12 associative pairs. During a test phase, a half of the learned pairs were repeated and the other half were rearranged. Participants determined if each pair was intact or rearranged. The between-domain association condition presented face-building pairs and the within-domain association condition presented either face-face or building-building pairs. As results, although behavioral performance of associative recognition was not different between the two conditions, many clusters in the hippocampus and the other brain areas showed greater activation in the between-domain association condition both during learning and test phases, confirming and extending a previous observation (Piekema et al., 2009). In the hippocampus, while such clusters were not spatially overlapped between learning and test phases, the clusters defined in the learning phase produced patterns of activation similar to the test phase. Overall, the current study demonstrates that perceptual and conceptual similarity of memory items affects hippocampal activity and suggests that theoretical and empirical understanding about domain is useful to investigate binding functions in the hippocampus.

keywords
hippocampus, associative memory, domain, fMRI, 해마, 연합 기억, 범주, 기능성자기공명영상(fMRI)

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