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ISSN : 1226-9654

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Vol.28 No.4

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Aging and Efficiency of Brain Functional Networks: Preliminary Study in Korean Women

The Korean Journal of Cognitive and Biological Psychology / The Korean Journal of Cognitive and Biological Psychology, (P)1226-9654; (E)2733-466X
2016, v.28 no.4, pp.675-682
https://doi.org/10.22172/cogbio.2016.28.4.004


& (2016). Aging and Efficiency of Brain Functional Networks: Preliminary Study in Korean Women. The Korean Journal of Cognitive and Biological Psychology, 28(4), 675-682, https://doi.org/10.22172/cogbio.2016.28.4.004

Abstract

The human brain networks are organized with two fundamental principles, i.e. segregation and integration, for efficient information processing. This study investigated age-related changes in the brain networks of Korean women, using resting-state fMRI and focusing on local efficiency and global efficiency that represent segregation and integration respectively. Fourteen young adults and 28 old adults participated. Old adults had lower global efficiency but higher local efficiency in the functional brain networks compared with young adults. In addition, global efficiency of old adults was positively associated with the KDRS-2 scores at trend level, and their local efficiency was negatively correlated with the KDRS-2 scores. These results suggest that global integration of the brain network may reduce but short-range local connection increase with aging. In old adults, lower network integration and higher local connection seems to be linked lower cognitive function.

keywords
노화, 기능적 연결성, 그래프 이론 분석, 전반적 효율성, 국소적 효율성, brain aging, functional connectivity, graph theoretical analysis, global efficiency, local efficiency

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